PXD052730

PXD052730 is an original dataset announced via ProteomeXchange.

Title	Timed topical dexamethasone eye drops improve mitochondrial function to suppress severe retinopathy of prematurity.
Description	Pathological neovascularization (NV) can cause visual impairment in retinopathy of prematurity (ROP). Current treatments addressing vasoproliferative (Phase II) ROP are costly and can lead to severe complications. We show that well-timed topical 0.1% dexamethasone eye drops during early retinal neovascular formation prevents NV in five extremely preterm infants at high risk for ROP and in mouse oxygen-induced retinopathy (OIR) modeling ROP. In OIR mice, daily treatment before any NV has limited efficacy in mitigating NV, while treatment after peak NV exhibits no statistically significant effect but with a trend to exacerbating NV. Optimally timed topical dexamethasone suppression of NV in OIR is associated with increased retinal mitochondrial gene expression and a decrease in inflammatory markers predominantly expressed in immune cells. This study provides new insights into topical steroid effects in retinal NV and into mitochondrial function in phase II ROP, and suggests a simple approach to preventing severe ROP.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_18:18:42.294.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD052730
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Zhongjie Fu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-30 15:08:39	ID requested
⏵ 1	2025-05-06 18:18:43	announced

10.1007/s10456-024-09948-2;

Yagi H, Boeck M, Petrishka-Lozenska M, Lundgren P, Kasai T, Cagnone G, Neilsen K, Wang C, Lee J, Tomita Y, Singh SA, Joyal JS, Aikawa M, Negishi K, Fu Z, Hellstr, ö, m A, Smith LEH, Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity. Angiogenesis, 27(4):903-917(2024) [pubmed]

10.6019/PXD052730;

submitter keyword: Retinopathy of prematurity, steroid, oxygen-induced retinopathy, dexamethasone, eye drop

Zhongjie fu
contact affiliation	Boston Children's Hospital
contact email	Zhongjie.fu@childrens.harvard.edu
lab head
Zhongjie Fu
contact affiliation	Boston Children's Hospital
contact email	zhongjie.fu@childrens.harvard.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD052730
     1. Label: PRIDE project
     2. Name: Timed topical dexamethasone eye drops improve mitochondrial function to suppress severe retinopathy of prematurity.