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PXD052725

PXD052725 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleQuantitative serum proteomic analysis for potential biomarkers in post-COVID-19 onset Postural Orthostatic Tachycardia Syndrome (PC-POTS) patients
DescriptionPostural orthostatic tachycardia syndrome (POTS) is a chronic neurological disorder of the autonomic nervous system (ANS) that is characterized by an excessive increase in heart rate upon orthostatic challenge. The symptoms of POTS are often debilitating, and it primarily affects young females. Even prior to coronavirus disease 2019 (COVID-19) pandemic, POTS was prevalent, affecting an estimated 0.5% to 1% of the entire population in the United States (US). Since the COVID-19 pandemic, the incidence of POTS has acutely risen, adding roughly 6-7 million POTS patients in the US alone. Despite its importance, there is currently no reliable serum biomarker for POTS. One of the major hurdles in identifying biomarkers of POTS is the heterogenous nature of the clinical syndrome. To address this challenge, we focused our analysis on patients from the recent increase in cases of post-COVID-19 onset POTS (PC-POTS). We hypothesized that PC-POTS represents a relatively homogeneous subgroup of POTS, likely triggered by the same pathogen, and presents with symptoms that are more pronounced compared to those in healthy controls. We identified 752 proteins from 18 serum proteome samples composed of 9 PC-POTS patients and 9 health control (HC) individuals, and 31 proteins showed a significant protein abundance difference in PC-POTS. Notably, the majority of the elevated proteins are associated with either actin filaments or immune functions/inflammation. The Weighted Gene Co-Expression Network Analysis (WGCNA) revealed that the module 7 (M7) most highly correlated with the diagnosis also exhibited strong correlations with various sample traits such as the Orthostatic Intolerance Score, Gastrointestinal Score, Pupillomotor Score, and the COMPASS-31 score. The proteins MTPN, TAGLN2, ADP-ribosylation factor 1, PDLIM1, PPIA, CNN2, LGALSL, TXN, TLN1, TUBA4A, IL4, TREML1, GP1BA, and GP6 were identified as common proteins overlapping in various sample traits. Cell-type enrichment analysis revealed that M7 is highly associated with immune and neuronal cells. The main pathways identified in this module include the integrin signaling pathway, blood coagulation, and glycolysis. This suggests that these proteins could potentially serve as biomarkers for PC-POTS. This study utilizes mass spectrometry-based proteomic analysis to identify serum biomarkers that differentiate patients with PC-POTS from HC individuals, thus establishing a foundation for further research and validation.
HostingRepositoryPRIDE
AnnounceDate2025-05-08
AnnouncementXMLSubmission_2025-05-08_10:57:38.160.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterchanhyun na
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-30 10:22:08ID requested
12025-05-08 10:57:38announced
Publication List
10.1016/j.autneu.2025.103247;
Ryu T, Adler BL, Jeong SJ, Lee DC, Hoke A, Na CH, Chung T, Quantitative serum proteomic analysis for biomarker discovery in post-COVID-19 postural orthostatic tachycardia syndrome (PC-POTS) patients. Auton Neurosci, 258():103247(2025) [pubmed]
Keyword List
submitter keyword: Post-acute sequelae of COVID-19,Post-COVID-19 syndrome, mass spectrometry, Postural Orthostatic Tachycardia Syndrome, long COVID syndrome, tandem mass tag, serum proteomics, biomarker
Contact List
Chan-hyun Na
contact affiliationAssociate Professor of Neurology Institute for Cell Engineering Johns Hopkins University School of Medicine
contact emailchanhyun@jhmi.edu
lab head
chanhyun na
contact affiliationJohns Hopkins University
contact emailchanhyun.na@gmail.com
dataset submitter
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Dataset FTP location
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