PXD052714

PXD052714 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Analysis of neutrophil proteome of Barth syndrome patients
Description	Barth syndrome (BTHS) is a rare genetic disease caused by mutations in the TAFAZZIN gene. It is characterized by neutropenia, cardiomyopathy, and skeletal myopathy. Neutropenia in BTHS is associated with life-threatening infections, yet the molecular and physiological causes of this phenomenon are poorly understood. We conducted proteome analysis of circulating neutrophils from BTHS patients to identify upregulated and downregulated canonical pathways that may explain the disruptions in neutrophil maturation and function.
HostingRepository	PRIDE
AnnounceDate	2025-02-12
AnnouncementXML	Submission_2025-02-12_04:28:32.149.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Borko Amulic
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-30 06:38:56	ID requested
⏵ 1	2025-02-12 04:28:32	announced

Publication List

10.1038/S44319-025-00393-W;

10.1038/S44319-025-00393-W;

Keyword List

submitter keyword: neutrophil,Barth

submitter keyword: neutrophil,Barth

Contact List

Borko Amulic
contact affiliation	Amulic Lab, University of Bristol, School of Cellular and Molecular Medicine, Bristol, UK.
contact email	borko.amulic@bristol.ac.uk
lab head
Borko Amulic
contact affiliation	University of Bristol
contact email	borko.amulic@bristol.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD052714
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD052714

PRIDE project URI

Repository Record List

[ + ]