PXD052630 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Sex-Specific Proteomic Alterations in Pattern Hair Loss: Insights into Pathogenesis and Potential Therapeutic Targets |
| Description | This study presents a comprehensive comparative proteomic analysis aimed at elucidating the molecular mechanisms underlying male androgenetic alopecia (AGA) and female pattern hair loss (FPHL). Scalp samples from both AGA and FPHL patients, along with their respective normal controls, were subjected to proteomic analysis, followed by bioinformatics investigations. Our findings reveal distinct proteomic profiles between AGA and FPHL, with a total of 68 differentially expressed proteins (DEPs) identified in AGA and 84 DEPs in FPHL. Among these, specific proteins were altered in AGA and FPHL, highlighting sex-specific molecular pathways involved in the pathogenesis of pattern hair loss. Protein-protein interaction network analyses further delineated the biological processes most impacted, including cytoskeleton organization, stress response, and metabolic pathways, with particular emphasis on the differing altered stress responses and metabolic states associated with hair loss between sexes. Our study not only uncovers the complex molecular landscape of AGA and FPHL but also identifies potential biomarkers and therapeutic targets, offering new insights into the sex-specific pathogenesis of pattern hair loss |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-23 |
| AnnouncementXML | Submission_2026-06-23_01:33:02.491.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Poorichaya Somparn |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-05-28 06:04:11 | ID requested | |
| ⏵ 1 | 2026-06-23 01:33:03 | announced | |
Publication List
Keyword List
| submitter keyword: metabolism, proteomics, female pattern hair loss, stress response, pattern hair loss, protein,Androgenetic alopecia |
Contact List
| poorichaya somparn |
|---|
| contact affiliation | Center of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand |
| contact email | poorichaya.s@chula.ac.th |
| lab head | |
| Poorichaya Somparn |
|---|
| contact affiliation | Chulalongkorn university |
| contact email | poorichaya.s@chula.ac.th |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD052630 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052630
- Label: PRIDE project
- Name: Sex-Specific Proteomic Alterations in Pattern Hair Loss: Insights into Pathogenesis and Potential Therapeutic Targets
