PXD052629

PXD052629 is an original dataset announced via ProteomeXchange.

Title	Challenges in Allergenicity Assessment of Ulva sp. as a Novel Food Source
Description	Ulva sp., a promising yet underexplored food source, offers rich protein content and nutritional benefits. However, assessing its allergenicity remains challenging due to limited research and understanding. In this translational research, we focus on a laboratory-produced Ulva sp. product (UlvaLe) and gather comprehensive data to assess its potential allergenicity. Therefore, we employed a weight-of-evidence approach inspired by regulatory standards, conducting a literature review, proteomic analysis, and clinical trial. This article addresses challenges in assessing the allergenicity of novel foods, using Ulva sp. as an example, while enhancing the understanding of Ulva sp.'s allergenic potential and offers insights for future research and regulatory processes. Our findings reveal no reported cases of Ulva allergenicity in the literature but highlight the need to address polysaccharide safety. Proteins with homology exceeding 70% to known allergens were identified as putative allergens. Nonetheless, interim clinical trial results demonstrate no allergic reactions to UlvaLe ingestion, suggesting a favorable safety profile. The presented data suggests a promising allergenicity safety profile for UlvaLe as a novel food source. Further research into macro-algae allergenicity, including DNA and protein composition decoding, is warranted to ensure safe utilization in the food industry. Nevertheless, the most effective means of assessing allergenicity for any new food is through widespread consumption among large populations, which statistically reveals the true public risk. As a modern society seeking innovative solutions and sustainable growth, it is imperative to be mindful of this and devise strategies for its safe integration.
HostingRepository	PRIDE
AnnounceDate	2025-12-22
AnnouncementXML	Submission_2025-12-22_00:12:34.736.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Keren Bendalak
SpeciesList	scientific name: Ulvophyceae; NCBI TaxID: NEWT:33103;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-28 05:45:11	ID requested
⏵ 1	2025-12-22 00:12:35	announced

10.1038/S41538-025-00638-X;

submitter keyword: Novel Food, Allergenicity Assessment, macro-algae, Allergenicity, sequence homology,Ulva, weigh-of-evidence, clinical trial

Ronit Confino-Cohen
contact affiliation	Allergy and Clinical Immunology Unit, Meir Medical Center, Kfar Saba, Israel Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel
contact email	ronitco@clalit.org.il
lab head
Keren Bendalak
contact affiliation	Technion
contact email	kerenb@technion.ac.il
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD052629
     1. Label: PRIDE project
     2. Name: Challenges in Allergenicity Assessment of Ulva sp. as a Novel Food Source