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PXD052590

PXD052590 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCharacterization of the choroid plexus role in Alzheimer’s disease pathophysiology
DescriptionStructural and functional changes of the choroid plexus (ChP) have been reported in Alzheimer’s disease (AD). Nonetheless, the role of the ChP in the pathogenesis of AD remains largely unknown. We aim to unravel the relation between ChP functioning and core AD pathogenesis using a unique proteomic approach in mice and humans. We used an APP knock-in mouse model, APPNL-G-F, exhibiting amyloid pathology, to study the association between AD brain pathology and protein changes in mouse ChP tissue and CSF using liquid chromatography mass spectrometry. Mouse proteomes were investigated at the age of 7 weeks (n=5) and 40 weeks (n=5). Results were compared with existing human AD CSF proteomic data (n=496) to identify key proteins and pathways associated with ChP changes in AD.
HostingRepositoryPRIDE
AnnounceDate2024-08-11
AnnouncementXMLSubmission_2024-08-10_16:40:23.738.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSara Dufour
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-27 06:08:55ID requested
12024-08-10 16:40:24announced
Publication List
10.1186/s12987-024-00555-3;
Delvenne A, Vandendriessche C, Gobom J, Burgelman M, Dujardin P, De Nolf C, Tijms BM, Teunissen CE, Schindler SE, Verhey F, Ramakers I, Martinez-Lage P, Tainta M, Vandenberghe R, Schaeverbeke J, Engelborghs S, De Roeck E, Popp J, Peyratout G, Tsolaki M, Freund-Levi Y, Lovestone S, Streffer J, Bertram L, Blennow K, Zetterberg H, Visser PJ, Vandenbroucke RE, Vos SJB, Involvement of the choroid plexus in Alzheimer's disease pathophysiology: findings from mouse and human proteomic studies. Fluids Barriers CNS, 21(1):58(2024) [pubmed]
Keyword List
submitter keyword: Choroid plexus,Alzheimer’s disease, Cerebrospinal fluid, Amyloid-β (Aβ)., Proteomics, APP knock-in mice
Contact List
Aurore Delvenne
contact affiliationDepartment of Psychiatry and Neuropsychology, Alzheimer Centrum Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands
contact emaila.delvenne@maastrichtuniversity.nl
lab head
Sara Dufour
contact affiliationVIB-UGent
contact emailsara.dufour@vib-ugent.be
dataset submitter
Full Dataset Link List
Dataset FTP location
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