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PXD052513

PXD052513 is an original dataset announced via ProteomeXchange.

Dataset Summary
Titlerotein expression in Nav1.7 embryonic null mice – mechanisms of compensation
DescriptionMice and humans who have lost the expression of functional sodium channel Nav1.7 are pain-free, but otherwise normal. This is the result of a loss of neurotransmitter release such as glutamate and Substance P from primary sensory neurons. The sensory neurons are otherwise normal apart from loss of neurotransmitter release. Adult gene deletion results in a loss of neuronal excitability with some analgesia that is not linked to opioid activity. Drugs that block Nav1.7 have lethal effects through action on the autonomic nervous system and the heart. But the embryonic null humans and mice are fine. Therefore there must be compensation for the embryonic loss of Nav1.7. This experiment compares the protein components of wild type normal mice and Nav1.7 embryonic deletion mice in order to identify compensatory mechanisms.
HostingRepositoryPRIDE
AnnounceDate2024-10-17
AnnouncementXMLSubmission_2024-10-17_07:21:42.321.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterriccardo zenezini chiozzi
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-23 04:52:23ID requested
12024-10-17 07:21:42announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: two mechanisms of analgesia, drugs,Pain, humans, autonomic side-effects, embryonic and adult nulls, sodium channels, mice, Nav1.7, opioid signalling
Contact List
Konstantinos Thalassinos
contact affiliationStructural & Molecular Biology, UCL London, UK
contact emailk.thalassinos@ucl.ac.uk
lab head
riccardo zenezini chiozzi
contact affiliationUCL
contact emailr.chiozzi@ucl.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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