PXD052488

PXD052488 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Multi-omics characterization of childhood rhabdomyosarcoma
Description	Rhabdomyosarcoma (RMS) presents a significant challenge in the field of oncology as a high-grade, aggressive soft tissue sarcoma that originates from skeletal (striated) muscle cells which do not fully differentiate. This condition is characterized by two major molecular and histopathological subtypes: 'alveolar' RMS (ARMS) and 'embryonic' RMS (ERMS), each driven by unique underlying mechanisms. The disease's inherent heterogeneity, complex genetic makeup, and limited therapeutic options highlight the need for innovative research approaches to understand its complexities. Through the use of transcriptomics, alongside an exploration of proteomics, researchers have identified dysregulated proteins common to both subtypes, offering insights into the pathophysiology and aggressiveness of RMS. Additionally, metabolomics sheds light on metabolic pathways linked to RMS perturbation. The integration of high-throughput omics ‘Multi-omics’ technologies thus provides unprecedented opportunities to dissect the molecular intricacies of cancer biology, offering avenues for enhanced understanding and targeted interventions in RMS.
HostingRepository	PRIDE
AnnounceDate	2025-08-04
AnnouncementXML	Submission_2025-08-03_20:56:40.479.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sameh Magdeldin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-22 13:55:34	ID requested
⏵ 1	2025-08-03 20:56:41	announced

Publication List

10.3390/cells14141115;
Osama A, Karam A, Atef A, Arafat M, Afifi RW, Mokhtar M, Abdelmoneim TK, Ramzy A, El Nadi E, Salama A, Elzayat E, Magdeldin S, Integrative Multi-Omics Profiling of Rhabdomyosarcoma Subtypes Reveals Distinct Molecular Pathways and Biomarker Signatures. Cells, 14(14):(2025) [pubmed]

10.3390/cells14141115;

Osama A, Karam A, Atef A, Arafat M, Afifi RW, Mokhtar M, Abdelmoneim TK, Ramzy A, El Nadi E, Salama A, Elzayat E, Magdeldin S, Integrative Multi-Omics Profiling of Rhabdomyosarcoma Subtypes Reveals Distinct Molecular Pathways and Biomarker Signatures. Cells, 14(14):(2025) [pubmed]

Keyword List

submitter keyword: multiomics,proteomics, metabolomics

submitter keyword: multiomics,proteomics, metabolomics

Contact List

Sameh Magdeldin
contact affiliation	Lab head's proteomics and metabolomics program basic research 57357
contact email	sameh.magdeldin@57357.org
lab head
Sameh Magdeldin
contact affiliation	Proteomics and Metabolomics Research Program, Basic Research Department, Children’s Cancer Hospital, (CCHE-57357), Cairo 57357, Egypt
contact email	proteomicslab2017@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD052488
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD052488

PRIDE project URI

Repository Record List

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