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PXD052470

PXD052470 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTMT-Based quantitative proteomics reveals the genetic mechanisms of secondary hair follicle development in the fine wool sheep foetus
DescriptionChinese Merino Sheep (Junken Type) is one of the fine wool sheep breeds in China, which is famous for producing fine wool. Wool quality including fibre diameter and length is the most concerned economic indicator for producers. Growth and development of secondary hair follicles (SFs) influences the wool quality. Understanding the formation mechanism of wool quality and related key proteins can help optimize and control the production of wool. However, The mechanism by which proteins mediate the development of SFs in the sheep foetus remains elusive. Here, based on the histomorphology of the SFs among four stages of foetus development (E75, E85, E95 and E105), the differential protein profiles of skin tissues were determined in three comparison pairs of foetus development (E75 versus E85, E85 versus E95, and E95 versus E105) by TMT-Based quantitative proteomics technology. With the help of proteomics technology, a total of 238, 35 and 348 differentially expressed proteins (DEPs) were identified in three comparison periods, respectively. In SFs development, focal adhesion, ECM−receptor interaction and estrogen signaling pathway, etc. played important role. COL1A1, THBS3, ITGA6, COL6A1 and THBS4 were potential candidate proteins in SF initiation. Overall, this study provided valuable proteomics data on the SFs development and a prospective understanding of the molecular mechanisms for wool quality traits in fine wool sheep.
HostingRepositoryPRIDE
AnnounceDate2025-05-07
AnnouncementXMLSubmission_2025-05-06_17:31:25.651.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterqiu lixia
SpeciesList scientific name: Ovis aries; NCBI TaxID: 9940;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-22 01:45:39ID requested
12025-05-06 17:31:26announced
Publication List
10.1371/journal.pone.0315637;
Qiu LX, Yu Q, Zhou HQ, Fan WH, Zheng JJ, Yang YL, Zhang WZ, Cao X, Yang H, TMT-based quantitative proteomics reveals the genetic mechanisms of secondary hair follicle development in fine-wool sheep. PLoS One, 20(2):e0315637(2025) [pubmed]
Keyword List
submitter keyword: TMT-based quantitative proteomic analysis, Skin,Sheep, Secondary hair follicle
Contact List
Hua Yang
contact affiliationState Key Laboratory of Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural and Reclamation Science, Shihezi, China
contact emailyhxjcn@sina.com
lab head
qiu lixia
contact affiliationNorthwest Minzu University
contact emailqiulixia1811942@163.com
dataset submitter
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Dataset FTP location
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