PXD052468

PXD052468 is an original dataset announced via ProteomeXchange.

Title	Genetic Control Over Biogenic Crystal Morphogenesis in Zebrafish
Description	Organisms had to evolve mechanisms that regulate the properties of biogenic crystals to support a wide range of functions, from vision and camouflage to communication and thermal regulation. Yet, the mechanism underlying the formation of diverse intracellular crystals remains enigmatic. Here, we have unraveled the bio-chemical control over crystal morphogenesis in zebrafish iridophores. We show that the chemical composition of the crystals determines their shape, specifically by the ratio between the nucleobases guanine and hypoxanthine. Moreover, we reveal that these variations in composition are genetically controlled through tissue-specific expression of specialized paralogues, which exhibits remarkable substrate selectivity. This orchestrated combination grants the organism with the capacity to generate a broad spectrum of crystal morphologies. Overall, our findings suggest a new mechanism for the morphological and functional diversity of biogenic crystals and may thus inspire the development of genetically designed biomaterials and medical therapeutics.
HostingRepository	PRIDE
AnnounceDate	2024-07-31
AnnouncementXML	Submission_2024-07-31_01:46:21.819.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD052468
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Meital Kupervaser
SpeciesList	scientific name: Danio rerio (Zebrafish) (Brachydanio rerio); NCBI TaxID: 7955;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-22 01:19:05	ID requested
⏵ 1	2024-07-31 01:46:22	announced

10.6019/PXD052468;

submitter keyword: Guanine,Iridophore, Substrate selectivity, Controlled biosynthesis, Paralogous enzymes, Crystal morphogenesis

Dvir Gur
contact affiliation	Department of Molecular Genetics, Weizmann Institute of Science; Rehovot, 7610001, Israel
contact email	dvir.gur@weizmann.ac.il
lab head
Meital Kupervaser
contact affiliation	Weizmann Institute of Science
contact email	meital.kupervaser@weizmann.ac.il
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD052468
     1. Label: PRIDE project
     2. Name: Genetic Control Over Biogenic Crystal Morphogenesis in Zebrafish