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PXD052426

PXD052426 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Chemical proteomic profiling of protein dopaminylation in colorectal cancer cells
Description	Histone dopaminylation is a newly identified epigenetic mark that plays a role in the regulation of gene transcription, where an isopeptide bond is formed between the fifth amino acid residue of H3 (i.e., glutamine) and dopamine. In our previous studies, we discovered that the dynamics of this post-translational modification (including installation, removal, and replacement) were regulated by a single enzyme, transglutaminase 2 (TGM2), through reversible transamination. Recently, we developed a chemical probe to specifically label and enrich histone dopaminylation via bioorthogonal chemistry.
HostingRepository	iProX
AnnounceDate	2024-05-21
AnnouncementXML	Submission_2024-05-20_20:05:24.661.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nan
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-20 20:04:59	ID requested
⏵ 1	2024-05-20 20:05:25	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: Probe, proteomic, dopaminylation

Contact List

Qingfei Zheng
contact affiliation	The Ohio State University
contact email	nanzhangwe@outlook.com
lab head
Nan
contact affiliation	The Ohio State University
contact email	bukesiyi1100@126.com
dataset submitter

Full Dataset Link List

iProX dataset URI