PXD052312

PXD052312 is an original dataset announced via ProteomeXchange.

Title	Proteome analysis in M. abscessus to study intrabacterial lipid inclusion
Description	During infection and granuloma formation, pathogenic mycobacteria accumulate triacylglycerol in the form of Intrabacterial Lipid Inclusions (ILI). These organelles facilitate bacterial evasion from the immune system and serve as a carbon source to sustain bacterial persistence within the infected host., a rapidly-growing non-tuberculous opportunistic pathogen, was previously shown to generate similar structures throughout their infectious cycle. In this proteomics study, M. abscessus was used as a model organism to identify, at a global level, the ILI-associated proteins (IAP) involved in ILI accumulation.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_17:03:52.293.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luc Camoin
SpeciesList	scientific name: Mycobacterium tuberculosis; NCBI TaxID: NCBITaxon:1773; scientific name: Mycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543); NCBI TaxID: 561007;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-16 05:40:34	ID requested
⏵ 1	2025-05-06 17:03:53	announced

10.1128/mbio.01475-24;

Dargham T, Aguilera-Correa JJ, Avellan R, Mallick I, Celik L, Santucci P, Brasseur G, Poncin I, Point V, Audebert S, Camoin L, Daher W, Cavalier J-F, Kremer L, Canaan S, A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria. mBio, 16(4):e0147524(2025) [pubmed]

submitter keyword: Mycobacterial abscessus proteome

Luc Camoin
contact affiliation	Aix-Marseille Univ., INSERM, CNRS, Institut Paoli-Calmettes, CRCM, Marseille Protéomique
contact email	luc.camoin@inserm.fr
lab head
Luc Camoin
contact affiliation	Life Sciences
contact email	luc.camoin@inserm.fr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD052312
     1. Label: PRIDE project
     2. Name: Proteome analysis in M. abscessus to study intrabacterial lipid inclusion