PXD052310 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria |
Description | During infection and granuloma formation, pathogenic mycobacteria accumulate triacylglycerol in the form of Intrabacterial Lipid Inclusions (ILI). These organelles facilitate bacterial evasion from the immune system and serve as a carbon source to sustain bacterial persistence within the infected host. M. abscessus, a rapidly-growing non-tuberculous opportunistic pathogen, was previously shown to generate similar structures throughout their infectious cycle. Herein, it was used as a model organism to identify, at a global level, the ILI-associated proteins (IAP) involved in ILI accumulation. By implementing the APEX2 proximity labeling method using an in vitro model for ILI accumulation, we identified 228 proteins potentially implicated in ILI biosynthesis. |
HostingRepository | PRIDE |
AnnounceDate | 2025-02-27 |
AnnouncementXML | Submission_2025-02-27_11:44:23.178.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | AUDEBERT Stephane |
SpeciesList | scientific name: Mycobacterium tuberculosis; NCBI TaxID: NCBITaxon:1773; scientific name: Mycobacterium abscessus; NCBI TaxID: 36809; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-05-16 05:39:02 | ID requested | |
⏵ 1 | 2025-02-27 11:44:24 | announced | |
Publication List
10.1128/mbio.01475-24; |
Dargham T, Aguilera-Correa JJ, Avellan R, Mallick I, Celik L, Santucci P, Brasseur G, Poncin I, Point V, Audebert S, Camoin L, Daher W, Cavalier J-F, Kremer L, Canaan S, A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria. mBio, 16(4):e0147524(2025) [pubmed] |
Keyword List
submitter keyword: LC-MSMS,Intracellular lipid inclusion, lipid metabolism, APEX2, persistence, ILI-associated proteins, proteomic, Mycobacterium abscessus, proximity labelling |
Contact List
Stéphane Canaan, Ph. D |
contact affiliation | Stéphane Canaan, Ph. D , Group Leader, "Lipolysis and Bacterial Pathogenicity" Laboratory of Engineering of Macromolecular Systems UMR7255-CNRS, 31 Chemin Joseph-Aiguier 13402 MARSEILLE cedex 20 |
contact email | Stephane.canaan@imm.cnrs.fr |
lab head | |
AUDEBERT Stephane |
contact affiliation | Marseille Proteomic, Centre de Recherche en Cancérologie de Marseille, Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes, 27 Boulevard Leï Roure CS30059 13273 Marseille Cedex 09 France |
contact email | stephane.audebert@inserm.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052310
- Label: PRIDE project
- Name: A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria