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PXD052310

PXD052310 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria
DescriptionDuring infection and granuloma formation, pathogenic mycobacteria accumulate triacylglycerol in the form of Intrabacterial Lipid Inclusions (ILI). These organelles facilitate bacterial evasion from the immune system and serve as a carbon source to sustain bacterial persistence within the infected host. M. abscessus, a rapidly-growing non-tuberculous opportunistic pathogen, was previously shown to generate similar structures throughout their infectious cycle. Herein, it was used as a model organism to identify, at a global level, the ILI-associated proteins (IAP) involved in ILI accumulation. By implementing the APEX2 proximity labeling method using an in vitro model for ILI accumulation, we identified 228 proteins potentially implicated in ILI biosynthesis.
HostingRepositoryPRIDE
AnnounceDate2025-02-27
AnnouncementXMLSubmission_2025-02-27_11:44:23.178.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAUDEBERT Stephane
SpeciesList scientific name: Mycobacterium tuberculosis; NCBI TaxID: NCBITaxon:1773; scientific name: Mycobacterium abscessus; NCBI TaxID: 36809;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-16 05:39:02ID requested
12025-02-27 11:44:24announced
Publication List
10.1128/mbio.01475-24;
Dargham T, Aguilera-Correa JJ, Avellan R, Mallick I, Celik L, Santucci P, Brasseur G, Poncin I, Point V, Audebert S, Camoin L, Daher W, Cavalier J-F, Kremer L, Canaan S, A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria. mBio, 16(4):e0147524(2025) [pubmed]
Keyword List
submitter keyword: LC-MSMS,Intracellular lipid inclusion, lipid metabolism, APEX2, persistence, ILI-associated proteins, proteomic, Mycobacterium abscessus, proximity labelling
Contact List
Stéphane Canaan, Ph. D
contact affiliationStéphane Canaan, Ph. D , Group Leader, "Lipolysis and Bacterial Pathogenicity" Laboratory of Engineering of Macromolecular Systems UMR7255-CNRS, 31 Chemin Joseph-Aiguier 13402 MARSEILLE cedex 20
contact emailStephane.canaan@imm.cnrs.fr
lab head
AUDEBERT Stephane
contact affiliationMarseille Proteomic, Centre de Recherche en Cancérologie de Marseille, Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes, 27 Boulevard Leï Roure CS30059 13273 Marseille Cedex 09 France
contact emailstephane.audebert@inserm.fr
dataset submitter
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Dataset FTP location
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