PXD052294

PXD052294 is an original dataset announced via ProteomeXchange.

Title	USP10 knockout in human HCT116 cells
Description	USP10 is an important factor in the progression of colorectal cancer, as inhibition or silencing of USP10 attenuates the aggressive phenotype. USP10 regulates sensitivity to the two widely used EGFR inhibitors gefitinib and osimertinib. Mechanistically, we show that USP10 mediates its effects via the phosphatase INPP4B, which regulates the downstream PI3K/AKT/mTOR signaling pathway. Thus, our study demonstrates for the first time a novel link between USP10 and response to EGFR-targeted therapy.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_16:35:52.032.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kateryna Kubaichuk
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-16 05:21:28	ID requested
⏵ 1	2025-05-06 16:35:52	announced

Kubaichuk K, Seitz T, Bergmann U, Glumoff V, Mennerich D, Kietzmann T, Ubiquitin-specific protease 10 determines colorectal cancer outcome by modulating epidermal growth factor signaling via inositol polyphosphate-4-phosphatase type IIB. Oncogenesis, 13(1):37(2024) [pubmed]

10.1038/s41389-024-00538-x;

submitter keyword: USP10, colorectal cancer

Thomas Kietzmann
contact affiliation	Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland
contact email	thomas.kietzmann@oulu.fi
lab head
Kateryna Kubaichuk
contact affiliation	University of Oulu
contact email	kateryna.kubaichuk@oulu.fi
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD052294

PRIDE project URI

• PRIDE
  1. PXD052294
     1. Label: PRIDE project
     2. Name: USP10 knockout in human HCT116 cells