PXD052262
PXD052262 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | YjbH contributes to S. aureus skin pathology and immune response through Agr-mediated alpha-toxin regulation |
Description | Staphylococcus aureus is a global health threat that can cause a multitude of diseases in many different areas of the body and is the leading cause of skin infections. This bacterium can produce a variety of proteins that contribute to virulence and disease progression. These virulence factors include alpha-hemolysin (Hla), which can kill many different cell types in the human body. In this study, we identified a new protein that contributes to Hla production, YjbH. It does so by controlling the activity of the Accessory Gene Regulator (Agr), a major player in the modulation of proteins produced in the bacterium. We demonstrate that without YjbH, S. aureus cultures produce less Hla, and this is corroborated during infection. Accordingly, when YjbH is present, tissue damage is greater during infection than when it is absent. Overall, our study sheds light on the complex regulation involved in virulence factor production by S. aureus and its ability to cause a wide range of diseases. |
HostingRepository | MassIVE |
AnnounceDate | 2024-08-26 |
AnnouncementXML | Submission_2024-08-26_09:35:27.710.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Michaella Rekowski |
SpeciesList | scientific name: Staphylococcus aureus subsp. aureus USA300; NCBI TaxID: 367830; |
ModificationList | Oxidation; Carbamidomethyl |
Instrument | Orbitrap Ascend |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-05-14 08:46:03 | ID requested | |
⏵ 1 | 2024-08-26 09:35:28 | announced |
Publication List
no publication |
Keyword List
submitter keyword: YjbH, alpha-toxin regulatioin |
Contact List
Jeffrey L. Bose | |
---|---|
contact affiliation | University of Kansas Medical Center |
contact email | jbose@kumc.edu |
lab head | |
Michaella Rekowski | |
contact affiliation | University of Kansas Medical Center |
contact email | mrekowski@kumc.edu |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000094754/ |