PXD052262

PXD052262 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	YjbH contributes to S. aureus skin pathology and immune response through Agr-mediated alpha-toxin regulation
Description	Staphylococcus aureus is a global health threat that can cause a multitude of diseases in many different areas of the body and is the leading cause of skin infections. This bacterium can produce a variety of proteins that contribute to virulence and disease progression. These virulence factors include alpha-hemolysin (Hla), which can kill many different cell types in the human body. In this study, we identified a new protein that contributes to Hla production, YjbH. It does so by controlling the activity of the Accessory Gene Regulator (Agr), a major player in the modulation of proteins produced in the bacterium. We demonstrate that without YjbH, S. aureus cultures produce less Hla, and this is corroborated during infection. Accordingly, when YjbH is present, tissue damage is greater during infection than when it is absent. Overall, our study sheds light on the complex regulation involved in virulence factor production by S. aureus and its ability to cause a wide range of diseases.
HostingRepository	MassIVE
AnnounceDate	2024-08-26
AnnouncementXML	Submission_2024-08-26_09:35:27.710.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Michaella Rekowski
SpeciesList	scientific name: Staphylococcus aureus subsp. aureus USA300; NCBI TaxID: 367830;
ModificationList	Oxidation; Carbamidomethyl
Instrument	Orbitrap Ascend

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-14 08:46:03	ID requested
⏵ 1	2024-08-26 09:35:28	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: YjbH, alpha-toxin regulatioin

submitter keyword: YjbH, alpha-toxin regulatioin

Contact List

Jeffrey L. Bose
contact affiliation	University of Kansas Medical Center
contact email	jbose@kumc.edu
lab head
Michaella Rekowski
contact affiliation	University of Kansas Medical Center
contact email	mrekowski@kumc.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000094754/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000094754/