PXD052222

PXD052222 is an original dataset announced via ProteomeXchange.

Title	Proteomics and metabolomics profiles of unvaccinated nonagenarian patients with severe SARS-CoV-2 infection
Description	The emergence of the coronavirus, SARS-CoV-2, in late 2019 led to a global pandemic with millions of confirmed cases and fatalities. The mortality rate rises significantly in patients over 90 years old; however, there are cases of older adults who survived or were not even infected despite being exposed. In this context, we aim to analyze the plasma proteomic and metabolomic profiles of nonagenarian patients who recovered (Group R) or died (Group D) from severe COVID-19 and compare them with non-infected control subjects (Group C). Plasma samples from the deceased group were collected days before the patients died, whereas plasma from survivors and non-infected individuals exposed to SARS-CoV-2 was collected 1-3 months after the reported infection or exposure. When compared to the control group, non-survivors showed a reduced abundance of specific lipid-related proteins and metabolites, including APOH, APOC1, LCAT, 7-α-25-dihydroxycholesterol, 7-dehydrocholesterol, and phosphatidylethanolamine which may serve as indicative markers of severity. These patients also exhibited elevated levels of N-heterocyclic compounds, potentially indicating an antiviral response. Recovered patients showed minimal differences compared to healthy non-infected subjects, indicating restoration of disrupted metabolic and proteomic profiles. However, proteins associated with acute phase response and complement activation did not return to normal levels. Also, specific metabolites, such as sphingolipids and phospholipids, remain altered in survival nonagenarians even after recovery, indicating persistent effects of COVID-19 infection. Alterations in proteins associated with neuronal function indicate possible brain damage and long-term neurological effects of COVID-19 infection.
HostingRepository	PRIDE
AnnounceDate	2025-11-17
AnnouncementXML	Submission_2025-11-17_00:32:32.565.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Proteomics Unit
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-13 07:50:12	ID requested
⏵ 1	2025-11-17 00:32:33	announced

Qui, ñ, ones-Vega M, Sosa-Acosta P, Guedes JS, Pinto de Almeida N, V de Castro M, Silva MVR, Dell'Aquila LP, Razuk-Filho Á, Batista-J, ú, nior PB, Zatz M, Nogueira FCS, Domont GB, Proteomics and Metabolomics Profiles of Unvaccinated Nonagenarian Patients with Severe SARS-CoV-2 Infection. J Proteome Res, 24(11):5453-5466(2025) [pubmed]

10.1021/acs.jproteome.5c00251;

ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project, Plasma (B/D-HPP)

submitter keyword: mass spectrometry

COVID-19

nonagenarians

plasma

proteomics

metabolomics

Fábio César Sousa Nogueira
contact affiliation	Unidade Proteômica, Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro; Laboratório de Proteômica (LabProt), LADETEC, Instituto de Química, Universidade Federal do Rio de Janeiro; Centro de Pesquisa em Medicina de Precisão, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro
contact email	fabiocsn@gmail.com
lab head
Proteomics Unit
contact affiliation	UFRJ
contact email	unidadeproteomica@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD052222

PRIDE project URI

• PRIDE
  1. PXD052222
     1. Label: PRIDE project
     2. Name: Proteomics and metabolomics profiles of unvaccinated nonagenarian patients with severe SARS-CoV-2 infection