PXD052209 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | mTOR activity paces human blastocyst stage developmental progression |
Description | Many mammals can control the timing of gestation and birth by pausing embryonic development at the blastocyst stage. It is unknown whether the capacity to pause development is conserved, in general across mammals, and more specifically in humans. Activity of the growth regulating mTOR pathway governs developmental pausing in the mouse. Here we show a stage-specific capacity to delay the progression of human development via mTOR inhibition. In this context, human blastoids and pluripotent stem cells in naïve and naïve-like, but not primed, states can be induced to enter a dormant state, which is reversible at the functional and molecular level. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:58:26.788.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Richard Imre |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | timsTOF HT |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-05-13 04:12:46 | ID requested | |
1 | 2024-09-16 03:53:31 | announced | |
⏵ 2 | 2024-10-22 06:58:27 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: blastoid, embryonic stem cell, dormancy,diapause, mTOR |
Contact List
Nicolas Rivron |
contact affiliation | Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria |
contact email | nicolas.rivron@imba.oeaw.ac.at |
lab head | |
Richard Imre |
contact affiliation | IMBA Vienna |
contact email | richard.imre@imba.oeaw.ac.at |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD052209 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052209
- Label: PRIDE project
- Name: mTOR activity paces human blastocyst stage developmental progression