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PXD052190

PXD052190 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe bipolar disorder GWAS risk gene NEK4 modulates circadian fluctuations of murine emotional behaviors and synaptogenesis
DescriptionThrough integrative analyses of GWAS summary statistics, population genetic data and expression quantitative trait loci (eQTL) annotations, we found that elevated NEK4 expression in hippocampus was causatively linked to the risk of BD. To examine the biological impact of this gene, we generated NEK4 conditional knock-in mice in pyramidal neurons of the adult forebrain (NEK4 cKI mice) and NEK4 overexpression mice with adeno-associated virus (AAV) mediated in the dorsal hippocampus (NEK4 OE mice). Since NEK4 encodes a serine/threonine kinase, we explored the phosphoproteomic profiles of these mice at different time of the day and compared them with those of the control mice. We isolated the hippocampal proteins of the NEK4 OE mice and the control mice during day and night respectively (n = 3 for each group), and performed phosphorylated 4D-label-free quantitative proteomics analyses. After stringent quality control, 5376 quantifiable phosphorylated peptides were identified in 2415 phosphorylated proteins
HostingRepositoryiProX
AnnounceDate2024-05-11
AnnouncementXMLSubmission_2025-01-05_20:10:36.307.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMiao Li
SpeciesList scientific name: Mus ; NCBI TaxID: 10088;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-10 19:37:54ID requested
12024-10-15 22:57:35announced
22025-01-05 20:10:37announced2025-01-06: Add Publication.
Publication List
Yang ZH, Cai X, Zhang CY, Zhang Q, Li M, Ding ZL, Guo Y, Ma G, Yang CH, Guo L, Chang H, Wang C, Li M, Xiao X, NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice. Nat Commun, 15(1):9180(2024) [pubmed]
Keyword List
submitter keyword: Bipolar disorder, genome-wide association study, circadian fluctuations, emotional behaviors, dendritic spine morphogenesis, synaptogenesis
Contact List
Ming Li
contact affiliationKunming Institute of Zoology Chinese Academy of Sciences
contact emaillimingkiz@mail.kiz.ac.cn
lab head
Miao Li
contact affiliationKunming Institute of Zoology Chinese Academy of Sciences
contact emaillimiao1@mail.kiz.ac.cn
dataset submitter
Full Dataset Link List
iProX dataset URI