PXD052190
PXD052190 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | The bipolar disorder GWAS risk gene NEK4 modulates circadian fluctuations of murine emotional behaviors and synaptogenesis |
Description | Through integrative analyses of GWAS summary statistics, population genetic data and expression quantitative trait loci (eQTL) annotations, we found that elevated NEK4 expression in hippocampus was causatively linked to the risk of BD. To examine the biological impact of this gene, we generated NEK4 conditional knock-in mice in pyramidal neurons of the adult forebrain (NEK4 cKI mice) and NEK4 overexpression mice with adeno-associated virus (AAV) mediated in the dorsal hippocampus (NEK4 OE mice). Since NEK4 encodes a serine/threonine kinase, we explored the phosphoproteomic profiles of these mice at different time of the day and compared them with those of the control mice. We isolated the hippocampal proteins of the NEK4 OE mice and the control mice during day and night respectively (n = 3 for each group), and performed phosphorylated 4D-label-free quantitative proteomics analyses. After stringent quality control, 5376 quantifiable phosphorylated peptides were identified in 2415 phosphorylated proteins |
HostingRepository | iProX |
AnnounceDate | 2024-05-11 |
AnnouncementXML | Submission_2025-01-05_20:10:36.307.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Miao Li |
SpeciesList | scientific name: Mus |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-05-10 19:37:54 | ID requested | |
1 | 2024-10-15 22:57:35 | announced | |
⏵ 2 | 2025-01-05 20:10:37 | announced | 2025-01-06: Add Publication. |
Publication List
Yang ZH, Cai X, Zhang CY, Zhang Q, Li M, Ding ZL, Guo Y, Ma G, Yang CH, Guo L, Chang H, Wang C, Li M, Xiao X, NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice. Nat Commun, 15(1):9180(2024) [pubmed] |
Keyword List
submitter keyword: Bipolar disorder, genome-wide association study, circadian fluctuations, emotional behaviors, dendritic spine morphogenesis, synaptogenesis |
Contact List
Ming Li | |
---|---|
contact affiliation | Kunming Institute of Zoology Chinese Academy of Sciences |
contact email | limingkiz@mail.kiz.ac.cn |
lab head | |
Miao Li | |
contact affiliation | Kunming Institute of Zoology Chinese Academy of Sciences |
contact email | limiao1@mail.kiz.ac.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |