PXD052186
PXD052186 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | N-terminal processing of CSP in P. falciparum salivary gland sporozoites |
Description | Salivary gland sporozoites of the malaria parasite Plasmodium express a major surface coat protein, CSP. The N-terminus of this protein is hypothesized to be enzymatically processed, revealing a Gln residue which is then enzymatically converted pyro-Glu. We analyzed P. falciparum salivary gland sporozoites, recombinant PfCSP, and synthetic peptides in order to characterize this cleavage site and its conversion. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-07 |
AnnouncementXML | Submission_2025-05-06_16:09:05.436.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD052186 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Kristian Swearingen |
SpeciesList | scientific name: Plasmodium falciparum NF54; NCBI TaxID: 5843; |
ModificationList | 2-pyrrolidone-5-carboxylic acid (Gln) |
Instrument | Orbitrap Eclipse |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-05-10 14:13:08 | ID requested | |
⏵ 1 | 2025-05-06 16:09:06 | announced |
Publication List
10.6019/PXD052186; |
Dacon C, Moskovitz R, Swearingen K, Da Silva Pereira L, Flores-Garcia Y, Aleshnick M, Kanatani S, Flynn B, Molina-Cruz A, Wollenberg K, Traver M, Kirtley P, Purser L, Dillon M, Bonilla B, Franco A, Petros S, Kritzberg J, Tucker C, Paez GG, Gupta P, Shears MJ, Pazzi J, Edgar JM, Teng AA, Belmonte A, Oda K, Doumbo S, Krymskaya L, Skinner J, Li S, Ghosal S, Kayentao K, Ongoiba A, Vaughan A, Campo JJ, Traore B, Barillas-Mury C, Wijayalath W, Idris A, Crompton PD, Sinnis P, Wilder BK, Zavala F, Seder RA, Wilson IA, Tan J, Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein. Science, 387(6729):eadr0510(2025) [pubmed] |
10.1126/science.adr0510; |
Keyword List
submitter keyword: Plasmodium malaria sporozoites |
Contact List
Kristian Swearingen | |
---|---|
contact affiliation | Institute for Systems Biology |
contact email | kristian.swearingen@isbscience.org |
lab head | |
Kristian Swearingen | |
contact affiliation | Institute for Systems Biology |
contact email | kristian.swearingen@systemsbiology.org |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD052186 |
PRIDE project URI |
Repository Record List
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