⮝ Full datasets listing

PXD052186

PXD052186 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleN-terminal processing of CSP in P. falciparum salivary gland sporozoites
DescriptionSalivary gland sporozoites of the malaria parasite Plasmodium express a major surface coat protein, CSP. The N-terminus of this protein is hypothesized to be enzymatically processed, revealing a Gln residue which is then enzymatically converted pyro-Glu. We analyzed P. falciparum salivary gland sporozoites, recombinant PfCSP, and synthetic peptides in order to characterize this cleavage site and its conversion.
HostingRepositoryPRIDE
AnnounceDate2025-05-07
AnnouncementXMLSubmission_2025-05-06_16:09:05.436.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD052186
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterKristian Swearingen
SpeciesList scientific name: Plasmodium falciparum NF54; NCBI TaxID: 5843;
ModificationList2-pyrrolidone-5-carboxylic acid (Gln)
InstrumentOrbitrap Eclipse
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-10 14:13:08ID requested
12025-05-06 16:09:06announced
Publication List
10.6019/PXD052186;
Dacon C, Moskovitz R, Swearingen K, Da Silva Pereira L, Flores-Garcia Y, Aleshnick M, Kanatani S, Flynn B, Molina-Cruz A, Wollenberg K, Traver M, Kirtley P, Purser L, Dillon M, Bonilla B, Franco A, Petros S, Kritzberg J, Tucker C, Paez GG, Gupta P, Shears MJ, Pazzi J, Edgar JM, Teng AA, Belmonte A, Oda K, Doumbo S, Krymskaya L, Skinner J, Li S, Ghosal S, Kayentao K, Ongoiba A, Vaughan A, Campo JJ, Traore B, Barillas-Mury C, Wijayalath W, Idris A, Crompton PD, Sinnis P, Wilder BK, Zavala F, Seder RA, Wilson IA, Tan J, Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein. Science, 387(6729):eadr0510(2025) [pubmed]
10.1126/science.adr0510;
Keyword List
submitter keyword: Plasmodium malaria sporozoites
Contact List
Kristian Swearingen
contact affiliationInstitute for Systems Biology
contact emailkristian.swearingen@isbscience.org
lab head
Kristian Swearingen
contact affiliationInstitute for Systems Biology
contact emailkristian.swearingen@systemsbiology.org
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD052186
PRIDE project URI
Repository Record List
[ + ]