PXD052185

PXD052185 is an original dataset announced via ProteomeXchange.

Title	B cell lymphocytes as a potential source of breast carcinoma marker candidates
Description	The prognostic correlation of tumor-infiltrating T cells has been widely studied in breast cancer, but tumor-infiltrating B cells have not received so much attention. The protein profile analysis of CD19+ B-lymphocytes in benign, Luminal A, Luminal B, and triple-negative breast cancer patients in comparison to healthy control via a label-free proteomic quantification was performed. We aimed to find a correlation between immunohistochemical results and proteomic approach in measuring the expression of proteins isolated from B-cell lymphocytes in peripheral blood samples. We identified 18 proteins with a significant fold change of more than 2, that have promising potential to serve as breast cancer biomarkers in the future since they are already either confirmed or proposed markers isolated directly from cancer tissue.
HostingRepository	PRIDE
AnnounceDate	2025-09-22
AnnouncementXML	Submission_2025-09-22_09:32:21.534.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD052185
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Miroslav Marcin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-10 13:20:46	ID requested
⏵ 1	2025-09-22 09:32:22	announced

10.3390/ijms25137351;

Tk, á, č, ikov, á S, Marcin M, Bober P, Kac, í, rov, á M, Š, ulikov, á M, Parnica J, T, ó, th D, Len, á, rt M, Rado, ň, ak J, Urdz, í, k P, Feda, č, ko J, Sabo J, B Cell Lymphocytes as a Potential Source of Breast Carcinoma Marker Candidates. Int J Mol Sci, 25(13):(2024) [pubmed]

10.6019/PXD052185;

submitter keyword: breast cancer

peripheral blood

lymphocyte B

proteomic analysis

mass spectrometry

CD19+ marker

Ján Sabo
contact affiliation	University of Pavol Jozef Šafárik in Košice
contact email	jan.sabo@upjs.sk
lab head
Miroslav Marcin
contact affiliation	University of Pavol Jozef Šafárik in Košice
contact email	miroslav.marcin@upjs.sk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD052185

PRIDE project URI

• PRIDE
  1. PXD052185
     1. Label: PRIDE project
     2. Name: B cell lymphocytes as a potential source of breast carcinoma marker candidates