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PXD052183

PXD052183 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLC-MS/MS analysis of the cation-independent mannose 6-phosphate receptor (CI-MPR) from bovine serum
DescriptionThe cation-independent mannose 6-phosphate receptor (CI-MPR) is clinically significant in the treatment of patients with lysosomal storage diseases because it functions in the biogenesis of lysosomes by transporting mannose 6-phosphate (M6P)-containing lysosomal enzymes to endosomal compartments. The extracellular region of CI-MPR comprises 15 homologous domains with binding sites for M6P-containing ligands located in domains 3, 5, 9, and 15, whereas IGF2 interacts with residues in domain 11. To evaluate the allosteric properties and conformation of CI-MPR, we isolated the receptor from a mammalian source, bovine serum and analyzed the sequence of the isolated receptor by mass spectrometry.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:39:40.585.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD052183
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMayumi Ishihara-Aoki
SpeciesList scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-10 11:33:46ID requested
12024-05-20 11:28:58announced
22024-10-22 06:39:41announced2024-10-22: Updated project metadata.
Publication List
10.6019/PXD052183;
Keyword List
submitter keyword: Bovine, CI-MPR, LC-MS/MS
Contact List
Kazuhiro Aoki
contact affiliationMedical College of Wisconsin
contact emailkaoki@mcw.edu
lab head
Mayumi Ishihara-Aoki
contact affiliationMedical College of Wisconsin
contact emailmaoki@mcw.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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