PXD052183

PXD052183 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	LC-MS/MS analysis of the cation-independent mannose 6-phosphate receptor (CI-MPR) from bovine serum
Description	The cation-independent mannose 6-phosphate receptor (CI-MPR) is clinically significant in the treatment of patients with lysosomal storage diseases because it functions in the biogenesis of lysosomes by transporting mannose 6-phosphate (M6P)-containing lysosomal enzymes to endosomal compartments. The extracellular region of CI-MPR comprises 15 homologous domains with binding sites for M6P-containing ligands located in domains 3, 5, 9, and 15, whereas IGF2 interacts with residues in domain 11. To evaluate the allosteric properties and conformation of CI-MPR, we isolated the receptor from a mammalian source, bovine serum and analyzed the sequence of the isolated receptor by mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:39:40.585.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD052183
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Mayumi Ishihara-Aoki
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-10 11:33:46	ID requested
1	2024-05-20 11:28:58	announced
⏵ 2	2024-10-22 06:39:41	announced	2024-10-22: Updated project metadata.

Publication List

10.6019/PXD052183;

10.6019/PXD052183;

Keyword List

submitter keyword: Bovine, CI-MPR, LC-MS/MS

submitter keyword: Bovine, CI-MPR, LC-MS/MS

Contact List

Kazuhiro Aoki
contact affiliation	Medical College of Wisconsin
contact email	kaoki@mcw.edu
lab head
Mayumi Ishihara-Aoki
contact affiliation	Medical College of Wisconsin
contact email	maoki@mcw.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD052183
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD052183

PRIDE project URI

Repository Record List

[ + ]