PXD052178
PXD052178 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics of E. coli extracellular vesicles |
Description | Escherichia coli A0 34/86 (EcO83) is a probiotic bacterium that is used in newborns to prevent nosocomial infections and diarrhoea. Mechanistically, EcO83 enhances innate immunity by inducing key inflammatory cytokines in vitro, and when administered intranasally, it modulates the recruitment of cells to the lung. This study investigates the immunomodulatory effects of EcO83-derived extracellular vesicles (EcO83-EVs) as a safer alternative to live bacteria. We isolated, purified, and characterised EcO83-EVs following the MISEV guidelines. The proteomics data of the EVs were compared with the proteomics data of cell extracts of the EcO83. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-07 |
AnnouncementXML | Submission_2025-05-06_16:02:40.610.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Johan Palmfeldt |
SpeciesList | scientific name: Escherichia coli; NCBI TaxID: 562; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-05-10 08:15:13 | ID requested | |
⏵ 1 | 2025-05-06 16:02:41 | announced |
Publication List
10.1002/jev2.70004; |
Razim A, Zab, ł, ocka A, Schmid A, Thaler M, Č, ern, ý V, Weinmayer T, Whitehead B, Martens A, Skalska M, Morandi M, Schmidt K, Wysmo, ł, ek ME, V, é, gv, á, ri A, Srutkova D, Schwarzer M, Neuninger L, Nejsum P, Hrd, ý J, Palmfeldt J, Brucale M, Valle F, G, ó, rska S, Wisgrill L, Inic-Kanada A, Wiedermann U, Schabussova I, Bacterial extracellular vesicles as intranasal postbiotics: Detailed characterization and interaction with airway cells. J Extracell Vesicles, 13(10):e70004(2024) [pubmed] |
Keyword List
submitter keyword: extracellular vesicles, E. coli, EcO83, proteome |
Contact List
Johan Palmfeldt | |
---|---|
contact affiliation | Aarhus University |
contact email | Johan.palmfeldt@clin.au.dk |
lab head | |
Johan Palmfeldt | |
contact affiliation | Aarhus University Hospital |
contact email | johan.palmfeldt@clin.au.dk |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD052178 |
PRIDE project URI |
Repository Record List
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