⮝ Full datasets listing

PXD052178

PXD052178 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics of E. coli extracellular vesicles
DescriptionEscherichia coli A0 34/86 (EcO83) is a probiotic bacterium that is used in newborns to prevent nosocomial infections and diarrhoea. Mechanistically, EcO83 enhances innate immunity by inducing key inflammatory cytokines in vitro, and when administered intranasally, it modulates the recruitment of cells to the lung. This study investigates the immunomodulatory effects of EcO83-derived extracellular vesicles (EcO83-EVs) as a safer alternative to live bacteria. We isolated, purified, and characterised EcO83-EVs following the MISEV guidelines. The proteomics data of the EVs were compared with the proteomics data of cell extracts of the EcO83.
HostingRepositoryPRIDE
AnnounceDate2025-05-07
AnnouncementXMLSubmission_2025-05-06_16:02:40.610.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJohan Palmfeldt
SpeciesList scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-10 08:15:13ID requested
12025-05-06 16:02:41announced
Publication List
10.1002/jev2.70004;
Razim A, Zab, ł, ocka A, Schmid A, Thaler M, Č, ern, ý V, Weinmayer T, Whitehead B, Martens A, Skalska M, Morandi M, Schmidt K, Wysmo, ł, ek ME, V, é, gv, á, ri A, Srutkova D, Schwarzer M, Neuninger L, Nejsum P, Hrd, ý J, Palmfeldt J, Brucale M, Valle F, G, ó, rska S, Wisgrill L, Inic-Kanada A, Wiedermann U, Schabussova I, Bacterial extracellular vesicles as intranasal postbiotics: Detailed characterization and interaction with airway cells. J Extracell Vesicles, 13(10):e70004(2024) [pubmed]
Keyword List
submitter keyword: extracellular vesicles, E. coli, EcO83, proteome
Contact List
Johan Palmfeldt
contact affiliationAarhus University
contact emailJohan.palmfeldt@clin.au.dk
lab head
Johan Palmfeldt
contact affiliationAarhus University Hospital
contact emailjohan.palmfeldt@clin.au.dk
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD052178
PRIDE project URI
Repository Record List
[ + ]