PXD052087 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | High transcriptional and proteomic abundance of the bromoform-synthesizing halogenase in seaweed Asparagopsis taxiformis revealed by a multi-omics investigation |
| Description | Halogenases, and the halogenated organic molecules that they furnish are thought to be highly specialized secondary metabolites produced in only modest amounts. The widespread production of bromoform by marine macroalgae contradicts this paradigm wherein up to 8% dry weight of the red seaweed Asparagopsis taxiformis comprises of this brominated natural product. In this study, using paired transcriptomic and proteomic workflows, we determine that the bromoform-producing halogenase in A. taxiformis, Mbb1, is one of the most abundant proteins in the seaweed tissue with proteomic abundance rivaling that of enzymes involved in photosynthesis and carbon fixation. The proteomic abundance of Mbb1 is matched by the high transcript abundance of the mbb1 gene. Production of Mbb1 was found independent of the ecological source of the seaweed tissue with comparable transcript abundances detected between stress-free laboratory-cultivated, and appropriately stressed field-collected tissue samples. Taken together, these findings allow us to posit that bromoform production is not a stress-response or self-defense mechanism for A. taxiformis and instead fulfills a core metabolic role in marine macroalgal physiology. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-16 |
| AnnouncementXML | Submission_2026-02-15_16:53:29.783.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD052087 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Shahima Islam |
| SpeciesList | scientific name: Asparagopsis taxiformis; NCBI TaxID: NEWT:260499; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-05-07 11:26:44 | ID requested | |
| ⏵ 1 | 2026-02-15 16:53:30 | announced | |
Publication List
| Lin Z, Islam S, Hargrave MS, Singh R, Zhou L, Xie R, Smith JE, Schmidt EW, Agarwal V, . Front Mar Sci, 12():(2025) [pubmed] |
| 10.3389/fmars.2025.1664275; |
| 10.6019/PXD052087; |
Keyword List
| submitter keyword: proteomics, bromoform, macroalgae, marine bromoform biosynthesis, algae, seaweed, Halogenase,Asparagopsis taxiformis, mbb |
Contact List
| Vinayak Agarwal |
|---|
| contact affiliation | School of Chemistry & Biochemistry College of Sciences Georgia Institute of Technology |
| contact email | vagarwal@gatech.edu |
| lab head | |
| Shahima Islam |
|---|
| contact affiliation | Georgia Institute of Technology |
| contact email | sislam71@gatech.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052087
- Label: PRIDE project
- Name: High transcriptional and proteomic abundance of the bromoform-synthesizing halogenase in seaweed Asparagopsis taxiformis revealed by a multi-omics investigation
