⮝ Full datasets listing

PXD052061

PXD052061 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleOxidised apolipoprotein peptidome characterise metabolic dysfunction-associated steatotic liver disease.Oxidised apolipoprotein peptidome characterise metabolic dysfunction-associated steatotic liver disease.
DescriptionA proteomic and peptidomics analysis of serum from patients suffering from metabolic dysfunction-associated steatotic liver disease. Proteomics was performed initially on a set of patients with varying degrees of liver disease. Following close analysis of the results, a peptidomics based analysis was performed and identified significant numbers of degraded and oxidised peptides from apolipoproteins. A more targeted peptidomics analysis was performed on a larger cohort and the oxidation status of small apolipoproteins demonstrated a high accuracy of precision for liver disease diagnosis.
HostingRepositoryPRIDE
AnnounceDate2025-01-21
AnnouncementXMLSubmission_2025-01-21_02:56:15.319.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD052061
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterRichard Kay
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListamidated residue; 2-pyrrolidone-5-carboxylic acid (Gln); acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-07 02:34:35ID requested
12025-01-21 02:56:16announced
Publication List
10.1111/liv.16200;
10.6019/PXD052061;
Mocciaro G, George AL, Allison M, Frontini M, Huang-Doran I, Reiman F, Gribble F, Griffin JL, Vidal-Puig A, Azzu V, Kay R, Vacca M, Oxidised Apolipoprotein Peptidome Characterises Metabolic Dysfunction-Associated Steatotic Liver Disease. Liver Int, 45(2):e16200(2025) [pubmed]
Keyword List
submitter keyword: peptidomics proteomics MASLD
Contact List
Fiona Gribble
contact affiliationInstitute of Metabolic Science, University of Cambridge
contact emailfmg23@cam.ac.uk
lab head
Richard Kay
contact affiliationUniversity of Cambridge
contact emailrgk27@medschl.cam.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD052061
PRIDE project URI
Repository Record List
[ + ]