PXD052061 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Oxidised apolipoprotein peptidome characterise metabolic dysfunction-associated steatotic liver disease.Oxidised apolipoprotein peptidome characterise metabolic dysfunction-associated steatotic liver disease. |
Description | A proteomic and peptidomics analysis of serum from patients suffering from metabolic dysfunction-associated steatotic liver disease. Proteomics was performed initially on a set of patients with varying degrees of liver disease. Following close analysis of the results, a peptidomics based analysis was performed and identified significant numbers of degraded and oxidised peptides from apolipoproteins. A more targeted peptidomics analysis was performed on a larger cohort and the oxidation status of small apolipoproteins demonstrated a high accuracy of precision for liver disease diagnosis. |
HostingRepository | PRIDE |
AnnounceDate | 2025-01-21 |
AnnouncementXML | Submission_2025-01-21_02:56:15.319.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD052061 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Richard Kay |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | amidated residue; 2-pyrrolidone-5-carboxylic acid (Gln); acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-05-07 02:34:35 | ID requested | |
⏵ 1 | 2025-01-21 02:56:16 | announced | |
Publication List
10.1111/liv.16200; |
10.6019/PXD052061; |
Mocciaro G, George AL, Allison M, Frontini M, Huang-Doran I, Reiman F, Gribble F, Griffin JL, Vidal-Puig A, Azzu V, Kay R, Vacca M, Oxidised Apolipoprotein Peptidome Characterises Metabolic Dysfunction-Associated Steatotic Liver Disease. Liver Int, 45(2):e16200(2025) [pubmed] |
Keyword List
submitter keyword: peptidomics proteomics MASLD |
Contact List
Fiona Gribble |
contact affiliation | Institute of Metabolic Science, University of Cambridge |
contact email | fmg23@cam.ac.uk |
lab head | |
Richard Kay |
contact affiliation | University of Cambridge |
contact email | rgk27@medschl.cam.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052061
- Label: PRIDE project
- Name: Oxidised apolipoprotein peptidome characterise metabolic dysfunction-associated steatotic liver disease.Oxidised apolipoprotein peptidome characterise metabolic dysfunction-associated steatotic liver disease.