PXD052041
PXD052041 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | ATPase activity of RIOK2 transports FADD–RIPK1–Caspase-8 complex from lysosome to ER and triggers spatial cleavage of GSDMD |
Description | We identified RIOK2 as a FADD-interacting protein that is essential for caspase-8-dependent cleavage of GSDMD. RIOK2’s ATPase activity drives the transport of lysosome to ER through activating myosin II and thereby translocate FADD-RIPK1-caspase-8 complex from lysosome to ER. Importantly, RIOK2’s ATPase activity also promotes the association of RIOK2 with FADD–RIPK1–caspase-8 complex and directly activates cleavage of caspase-8 and GSDMD both at ER and in vitro. |
HostingRepository | iProX |
AnnounceDate | 2024-05-07 |
AnnouncementXML | Submission_2024-05-06_20:47:46.038.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Mingtong Ma |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-05-06 20:47:16 | ID requested | |
⏵ 1 | 2024-05-06 20:47:46 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: ATPase, RIOK2, translocation, ER |
Contact List
Baoxue Ge | |
---|---|
contact affiliation | Tongji University |
contact email | baoxue_ge@tongji.edu.cn |
lab head | |
Mingtong Ma | |
contact affiliation | Tongji University |
contact email | mingtongma@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |