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PXD052040

PXD052040 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics and metabolomics analysis of rat upper carotid artery following Mongolian acupuncture therapy for T2DM atherosclerosis
DescriptionDiabetes mellitus (DM) is a chronic, noncommunicable disease, mainly due to insufficient insulin secretion or insulin sensitivity. Atherosclerosis is one of the major macrovascular complications of DM, and it is the main cause of death from clinical observation. Mongolian acupuncture therapy has the function of dredging meridians and regulating blood circulation, which has been proved to have unique efficacy and notable advantages in the treatment of DM and its common chronic complications. However, the effects and molecular mechanism of Mongolian acupuncture therapy in T2DM atherosclerosis remain unclear. The aim of this study is to explore the effect and molecular mechanism of streptozotocin and vitamin D3-induced T2DM atherosclerosis in rats, with or without Mongolian acupuncture therapy. The results of serum biochemical and histopathology analysis suggest that acupuncture therapy can improve cellular inflammatory factors, kidney function, serum lipid function and upper carotid artery tissue lesions in rat with T2DM atherosclerosis, which is an effective treatment method. In addition, we applied proteomics and metabolomics to comprehensively demonstrate that Mongolian acupuncture therapy in T2DM atherosclerosis mainly through regulation of lipid metabolism and amino acid metabolism. In general, our findings provide beneficial data support for future clinical studies of Mongolian acupuncture therapy in T2DM atherosclerosis.
HostingRepositoryiProX
AnnounceDate2024-05-07
AnnouncementXMLSubmission_2024-05-06_20:44:38.701.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXueyong Li
SpeciesList scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-06 20:44:15ID requested
12024-05-06 20:44:39announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: atherosclerosis, diabetes mellitus, lipid metabolism and amino acid metabolism, Mongolian acupuncture therapy, proteomics and metabolomics
Contact List
Wu Lan
contact affiliationSchool of Mongolian Medicine and Pharmacy, Inner Mongolia Medical University
contact email18947196075@163.com
lab head
Xueyong Li
contact affiliationInner Mongolia Medical University
contact email1324612868@qq.com
dataset submitter
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iProX dataset URI