PXD052040

PXD052040 is an original dataset announced via ProteomeXchange.

Title	Proteomics and metabolomics analysis of rat upper carotid artery following Mongolian acupuncture therapy for T2DM atherosclerosis
Description	Diabetes mellitus (DM) is a chronic, noncommunicable disease, mainly due to insufficient insulin secretion or insulin sensitivity. Atherosclerosis is one of the major macrovascular complications of DM, and it is the main cause of death from clinical observation. Mongolian acupuncture therapy has the function of dredging meridians and regulating blood circulation, which has been proved to have unique efficacy and notable advantages in the treatment of DM and its common chronic complications. However, the effects and molecular mechanism of Mongolian acupuncture therapy in T2DM atherosclerosis remain unclear. The aim of this study is to explore the effect and molecular mechanism of streptozotocin and vitamin D3-induced T2DM atherosclerosis in rats, with or without Mongolian acupuncture therapy. The results of serum biochemical and histopathology analysis suggest that acupuncture therapy can improve cellular inflammatory factors, kidney function, serum lipid function and upper carotid artery tissue lesions in rat with T2DM atherosclerosis, which is an effective treatment method. In addition, we applied proteomics and metabolomics to comprehensively demonstrate that Mongolian acupuncture therapy in T2DM atherosclerosis mainly through regulation of lipid metabolism and amino acid metabolism. In general, our findings provide beneficial data support for future clinical studies of Mongolian acupuncture therapy in T2DM atherosclerosis.
HostingRepository	iProX
AnnounceDate	2024-05-07
AnnouncementXML	Submission_2024-05-06_20:44:38.701.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xueyong Li
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-06 20:44:15	ID requested
⏵ 1	2024-05-06 20:44:39	announced

Dataset with its publication pending

submitter keyword: atherosclerosis, diabetes mellitus, lipid metabolism and amino acid metabolism, Mongolian acupuncture therapy, proteomics and metabolomics

Wu Lan
contact affiliation	School of Mongolian Medicine and Pharmacy, Inner Mongolia Medical University
contact email	18947196075@163.com
lab head
Xueyong Li
contact affiliation	Inner Mongolia Medical University
contact email	1324612868@qq.com
dataset submitter

iProX dataset URI