PXD052040
PXD052040 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics and metabolomics analysis of rat upper carotid artery following Mongolian acupuncture therapy for T2DM atherosclerosis |
Description | Diabetes mellitus (DM) is a chronic, noncommunicable disease, mainly due to insufficient insulin secretion or insulin sensitivity. Atherosclerosis is one of the major macrovascular complications of DM, and it is the main cause of death from clinical observation. Mongolian acupuncture therapy has the function of dredging meridians and regulating blood circulation, which has been proved to have unique efficacy and notable advantages in the treatment of DM and its common chronic complications. However, the effects and molecular mechanism of Mongolian acupuncture therapy in T2DM atherosclerosis remain unclear. The aim of this study is to explore the effect and molecular mechanism of streptozotocin and vitamin D3-induced T2DM atherosclerosis in rats, with or without Mongolian acupuncture therapy. The results of serum biochemical and histopathology analysis suggest that acupuncture therapy can improve cellular inflammatory factors, kidney function, serum lipid function and upper carotid artery tissue lesions in rat with T2DM atherosclerosis, which is an effective treatment method. In addition, we applied proteomics and metabolomics to comprehensively demonstrate that Mongolian acupuncture therapy in T2DM atherosclerosis mainly through regulation of lipid metabolism and amino acid metabolism. In general, our findings provide beneficial data support for future clinical studies of Mongolian acupuncture therapy in T2DM atherosclerosis. |
HostingRepository | iProX |
AnnounceDate | 2024-05-07 |
AnnouncementXML | Submission_2024-05-06_20:44:38.701.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Xueyong Li |
SpeciesList | scientific name: Rattus norvegicus; NCBI TaxID: 10116; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-05-06 20:44:15 | ID requested | |
⏵ 1 | 2024-05-06 20:44:39 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: atherosclerosis, diabetes mellitus, lipid metabolism and amino acid metabolism, Mongolian acupuncture therapy, proteomics and metabolomics |
Contact List
Wu Lan | |
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contact affiliation | School of Mongolian Medicine and Pharmacy, Inner Mongolia Medical University |
contact email | 18947196075@163.com |
lab head | |
Xueyong Li | |
contact affiliation | Inner Mongolia Medical University |
contact email | 1324612868@qq.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |