PXD052036

PXD052036 is an original dataset announced via ProteomeXchange.

Title	Disruption of ZC3H15 Compromises Telomere Length Maintenance by Sequestering Telomerase within Cajal bodies
Description	Telomere homeostasis, crucial for various biological processes, relies on telomerase activity. We identified ZC3H15 as a novel telomerase-interacting protein. Its deletion unexpectedly increased telomerase activity but led to shortened telomeres and cellular senescence. ZC3H15 interacts with telomerase and itself, regulating telomerase activity in an RNA-dependent manner. Proximity labeling showed ZC3H15's interaction with proteins involved in organelle assembly and RNA processes. Loss of ZC3H15 sequestered TERC in the Cajal body, reducing telomerase recruitment to telomeres during S phase. These findings unveil ZC3H15's role in telomere dynamics and cellular senescence, suggesting its potential as a target for cancer therapy or anti-aging interventions.
HostingRepository	iProX
AnnounceDate	2024-05-06
AnnouncementXML	Submission_2024-05-06_20:29:14.738.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chuanle Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-06 20:27:12	ID requested
⏵ 1	2024-05-06 20:29:15	announced

Dataset with its publication pending

submitter keyword: Telomere, Telomerase, Cajal body, ZC3H15

Yan Huang
contact affiliation	Sun Yat-Sen University
contact email	huangy336@mail.sysu.edu.cn
lab head
Chuanle Wang
contact affiliation	Sun Yat-Sen University
contact email	1415849898@qq.com
dataset submitter

iProX dataset URI