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PXD052033

PXD052033 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMicroenvironment Shapes Small Cell Lung Cancer Neuroendocrine States and Presents Unique Therapeutic Opportunities
DescriptionSmall-cell lung cancer (SCLC) is the most fatal form of lung cancer. Intra-tumoral heterogeneity, marked by neuroendocrine (NE) and non-neuroendocrine (non-NE) cell states, defines SCLC, but the drivers of SCLC plasticity are poorly understood. To map the landscape of SCLC tumor microenvironment (TME), we apply spatially resolved transcriptomics and quantitative mass spectrometry-based proteomics to metastatic SCLC tumors obtained via rapid autopsy. The phenotype and overall composition of non-malignant cells in the tumor microenvironment (TME) exhibits substantial variability, closely mirroring the tumor phenotype, suggesting TME-driven reprogramming of NE cell states. We identify cancer-associated fibroblasts (CAF) as a crucial element of SCLC TME heterogeneity, contributing to immune exclusion, and predicting an exceptionally poor prognosis. Together, our work provides the first comprehensive map of SCLC tumor and TME ecosystems, emphasizing their pivotal role in SCLCs adaptable nature, opening possibilities for re-programming the intercellular communications that shape SCLC tumor states.
HostingRepositoryPRIDE
AnnounceDate2024-05-15
AnnouncementXMLSubmission_2024-05-15_09:55:06.271.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterThomas Conrads
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-06 19:13:36ID requested
12024-05-15 09:55:06announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: small cell lung cancer
tumor microenvironment
tumor heterogeneity
spatial transcriptomics
cancer associated fibroblasts
intercellular communication
rapid research autopsy
Contact List
Thomas P. Conrads, PhD
contact affiliationDirector of Women’s Health Research Women’s Service Line Inova Health System
contact emailconrads@whirc.org
lab head
Thomas Conrads
contact affiliationInova Health System
contact emailconrads@whirc.org
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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