PXD051985

PXD051985 is an original dataset announced via ProteomeXchange.

Title	Peripheral Blood CD8+ T-Lymphocyte Immune Response in Benign and Subpopulations of Breast Cancer Patients
Description	Peripheral blood CD8+ T-lymphocytes play a crucial role in cell-mediated immunity and tumour-related immune responses in breast cancer. The protein profile analysis of CD8+ T-lymphocytes in benign, Luminal A, Luminal B and triple-negative breast cancer (TNBC) patients in comparison to healthy control via a label-free proteomic quantification and gene set enrichment analysis (GSEA) were performed. The results confirmed that the most significantly of RNA degradation signalling pathway was down-regulated in all groups (benign, Luminal A, Luminal B, TNBC) was observed. Given the immunological role that T cells play in the treatment of disease, a better knowledge of RNA metabolism, i.e., the role that mRNA degradation pathways play in human physiology and pathology may lead to novel approaches to the therapeutic use of T cells.
HostingRepository	PRIDE
AnnounceDate	2024-07-09
AnnouncementXML	Submission_2024-07-09_06:38:45.479.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD051985
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Miroslav Marcin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-04 14:27:12	ID requested
⏵ 1	2024-07-09 06:38:45	announced

10.6019/PXD051985;

submitter keyword: breast cancer

CD8+ T-lymphocytes

RNA degradation

granzymes

Ján Sabo
contact affiliation	Faculty of Medicine, Pavol Jozef Šafárik University in Košice
contact email	jan.sabo@upjs.sk
lab head
Miroslav Marcin
contact affiliation	University of Pavol Jozef Šafárik in Košice
contact email	miroslav.marcin@upjs.sk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD051985
     1. Label: PRIDE project
     2. Name: Peripheral Blood CD8+ T-Lymphocyte Immune Response in Benign and Subpopulations of Breast Cancer Patients