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PXD051972

PXD051972 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInsulin-Independent Regulation of Type 1 Diabetes via Large Brown Adipocyte-Secreted Proteins and the Novel Glucagon Regulator Nidogen-2
DescriptionCurrent treatments for type 1 diabetes (T1D) focus on optimizing insulin replacement. We demonstrate the therapeutic potential of the large secreted protein fraction from brown adipose tissue (BAT), independent of insulin. This secreted fraction mediates insulin receptor-dependent recovery of euglycemia in diabetic nonobese diabetic (NOD) mice by suppressing glucagon secretion. It also promotes white adipocyte differentiation and browning, and enhances glucose uptake in adipose tissue, skeletal muscle, and liver. From this fraction, we identify nidogen-2 as a brown adipocyte-secreted factor that reverses hyperglycemia in T1D NOD, inhibits glucagon secretion from pancreatic α-cells, and mimics other actions of the secreted fraction. These findings provide proof of principle that the pleiotropic effects of BAT-derived peptides represent a novel approach to diabetes management.
HostingRepositoryPRIDE
AnnounceDate2025-03-13
AnnouncementXMLSubmission_2025-03-13_07:33:28.613.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDennis Goldfarb
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Eclipse
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-03 08:37:41ID requested
12025-03-13 07:33:29announced
Publication List
10.2337/DB24-1003;
Keyword List
submitter keyword: Glucagon, Brown Adipose Tissue, Insulin,Diabetes
Contact List
David Piston
contact affiliationCell Biology and Physiology, Washington University in St. Louis
contact emailpiston@wustl.edu
lab head
Dennis Goldfarb
contact affiliationCell Biology and Physiology Institute for Informatics
contact emaild.goldfarb@wustl.edu
dataset submitter
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Dataset FTP location
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