PXD051941

PXD051941 is an original dataset announced via ProteomeXchange.

Title	Quantitative chemical proteomics profile target proteins of ITCs
Description	Quantitative chemical proteomics was performed to profile the target proteins of ITCs.For the forward SILAC experiment, heavy-labeled cells were treated with the ITC probe (20 μM) for 30 min and light-labeled cells were pre-treated with the natural ITC (60 μM) for 30 min, followed by the ITC probe (20 μM) for another 30 min. For the reverse SILAC experiment, light-labeled cells were treated with the ITC probe (20 μM) for 30 min and heavy-labeled cells were treated with the natural ITC (60 μM) for 30 min, followed by the ITC probe (20 μM) for another 30 min.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_15:43:23.470.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tao Peng
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-02 05:16:44	ID requested
⏵ 1	2025-05-06 15:43:24	announced

Dong X, Yu X, Lu M, Xu Y, Zhou L, Peng T, Quantitative chemical proteomics reveals that phenethyl isothiocyanate covalently targets BID to promote apoptosis. Cell Death Discov, 10(1):456(2024) [pubmed]

10.1038/s41420-024-02225-7;

submitter keyword: Human, SILAC, Chemical proteomics,Isothiocyanates, HF-X

Tao Peng
contact affiliation	Peking University Shenzhen Graduate School
contact email	tpeng@pku.edu.cn
lab head
Tao Peng
contact affiliation	Peking University Shenzhen Graduate School
contact email	penglab@yeah.net
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD051941

PRIDE project URI

• PRIDE
  1. PXD051941
     1. Label: PRIDE project
     2. Name: Quantitative chemical proteomics profile target proteins of ITCs