PXD051939

PXD051939 is an original dataset announced via ProteomeXchange.

Title	Plasma proteomics of Multisystem Inflammatory Syndrome in Children
Description	Multisystem inflammatory syndrome in Children (MIS-C) occurs in children between two and six weeks following an initial SARS-CoV-2 infection. The mechanism through which a minority of children develop the hyperinflammation characteristic of MIS-C, while others remain well, is unknown. In this study we present an in-depth assessment of the proteome of children before and after SARS-CoV-2 infection, including children with MIS-C. Reassuringly, these data show that there were minimal changes to the circulating proteome in healthy children as result of SARS-CoV2 infection and there was no evidence of continued inflammation following SARS-CoV-2 infection in children. However, activation of pro-inflammatory pathways and raised circulating markers of myocardial and vascular damage were found to be significantly associated with MIS-C. Our findings have been verified in silico using publicly available proteomic datasets and hence several promising candidate biomarker proteins for diagnosis of MIS-C are identified and described herein.
HostingRepository	PRIDE
AnnounceDate	2025-08-25
AnnouncementXML	Submission_2025-08-24_16:30:44.178.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Cathal Roarty
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	autoflex

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-02 04:10:49	ID requested
⏵ 1	2025-08-24 16:30:45	announced

Roarty C, Tonry C, McGinn C, Christie S, Waterfield T, Watson C, In depth characterisation of the proteome of MIS-C and post COVID-19 infection in children reveals inflammatory pathway activation and evidence of tissue damage. J Transl Med, 23(1):929(2025) [pubmed]

10.1186/s12967-025-06826-3;

submitter keyword: Human, Plasma, LC-MS/MS

Chris Watson
contact affiliation	QUB, WWIEM
contact email	chris.watson@qub.ac.uk
lab head
Cathal Roarty
contact affiliation	Queen's University, Belfast
contact email	croarty01@qub.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD051939

PRIDE project URI

• PRIDE
  1. PXD051939
     1. Label: PRIDE project
     2. Name: Plasma proteomics of Multisystem Inflammatory Syndrome in Children