PXD051831 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Molecular characterization of ribosome defective cell lines |
| Description | We generated a unique panel of isogenic cell models with the following genotypes via CRISPR-Cas9 engineering: Rpl5+/-, Rpl10 R98S, Rpl11+/-, Rpl22+/-, Rpl22-/-, Rps15 P131S and Rps15 H137Y. As cellular background, we chose for Ba/F3 cells. These are mouse lymphoid pro-B-cells, offering a relevant cellular background as most of these mutations have been linked to lymphoid malignancies as T-ALL and CLL. Quantitative proteomics profiling of this isogenic cell line panel shed a light on the molecular biology underlying the oncogenic mechanisms of these ribosomal lesions. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-18 |
| AnnouncementXML | Submission_2025-11-18_05:45:27.794.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Delphi Van Haver |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-04-29 00:12:13 | ID requested | |
| ⏵ 1 | 2025-11-18 05:45:28 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: cancer, proteomics,Mouse, Ba/F3, ribosome, CRISPR |
Contact List
| Kim De Keersmaecker |
|---|
| contact affiliation | Department of Oncology, KU Leuven |
| contact email | kim.dekeersmaecker@kuleuven.be |
| lab head | |
| Delphi Van Haver |
|---|
| contact affiliation | VIB Proteomics Core |
| contact email | delphi.vanhaver@vib-ugent.be |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD051831 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD051831
- Label: PRIDE project
- Name: Molecular characterization of ribosome defective cell lines
