PXD051811

PXD051811 is an original dataset announced via ProteomeXchange.

Title	Temperature-assisted limited proteolysis-coupled mass spectrometry approach to identify drug targets and binding sites in complex proteomes
Description	Drug target identification is an important premise of drug discovery and their mechanism investigation. In this study, we developed a temperature-assisted limited proteolysis-coupled mass spectrometry (TALiP-MS) method to systematically study drug binding targets and binding sites at the proteome level. We have proved that TALiP-MS was suitable for a variety of ligands, including cyclosporin A, geldanamycin and staurosporine.
HostingRepository	iProX
AnnounceDate	2024-04-26
AnnouncementXML	Submission_2024-04-27_22:42:47.639.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liu Yang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	TMT6plex reporter fragment
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-27 22:40:16	ID requested
⏵ 1	2024-04-27 22:42:48	announced

Dataset with its publication pending

submitter keyword: Limited proteolysis mass spectrometry (LiP-MS),thermal proteome profiling (TPP),drug targets

Wen Gao
contact affiliation	China Pharmaceutical University
contact email	gw_cpu@126.com
lab head
Liu Yang
contact affiliation	China Pharmaceutical University
contact email	m15735653961@163.com
dataset submitter

iProX dataset URI