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PXD051811

PXD051811 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTemperature-assisted limited proteolysis-coupled mass spectrometry approach to identify drug targets and binding sites in complex proteomes
DescriptionDrug target identification is an important premise of drug discovery and their mechanism investigation. In this study, we developed a temperature-assisted limited proteolysis-coupled mass spectrometry (TALiP-MS) method to systematically study drug binding targets and binding sites at the proteome level. We have proved that TALiP-MS was suitable for a variety of ligands, including cyclosporin A, geldanamycin and staurosporine.
HostingRepositoryiProX
AnnounceDate2024-04-26
AnnouncementXMLSubmission_2024-04-27_22:42:47.639.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLiu Yang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListTMT6plex reporter fragment
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-04-27 22:40:16ID requested
12024-04-27 22:42:48announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Limited proteolysis mass spectrometry (LiP-MS),thermal proteome profiling (TPP),drug targets
Contact List
Wen Gao
contact affiliationChina Pharmaceutical University
contact emailgw_cpu@126.com
lab head
Liu Yang
contact affiliationChina Pharmaceutical University
contact emailm15735653961@163.com
dataset submitter
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iProX dataset URI