PXD051811
PXD051811 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Temperature-assisted limited proteolysis-coupled mass spectrometry approach to identify drug targets and binding sites in complex proteomes |
Description | Drug target identification is an important premise of drug discovery and their mechanism investigation. In this study, we developed a temperature-assisted limited proteolysis-coupled mass spectrometry (TALiP-MS) method to systematically study drug binding targets and binding sites at the proteome level. We have proved that TALiP-MS was suitable for a variety of ligands, including cyclosporin A, geldanamycin and staurosporine. |
HostingRepository | iProX |
AnnounceDate | 2024-04-26 |
AnnouncementXML | Submission_2024-04-27_22:42:47.639.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Liu Yang |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | TMT6plex reporter fragment |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-04-27 22:40:16 | ID requested | |
⏵ 1 | 2024-04-27 22:42:48 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Limited proteolysis mass spectrometry (LiP-MS),thermal proteome profiling (TPP),drug targets |
Contact List
Wen Gao | |
---|---|
contact affiliation | China Pharmaceutical University |
contact email | gw_cpu@126.com |
lab head | |
Liu Yang | |
contact affiliation | China Pharmaceutical University |
contact email | m15735653961@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |