PXD051740

PXD051740 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of Post-COVID Condition: Insights from supernatant and pellet blood fractions
Description	Post-COVID condition (PCC), or long COVID, continues to significantly impact a considerable number of COVID-19 survivors, affecting their quality of life long after the initial infection. In a novel approach utilizing Sequential Window Acquisition of All Theoretical Mass Spectra (SWATH-MS) technology, a comprehensive proteomic analysis was conducted that included both plasma and the typically discarded residual blood fraction, known as the pellet. This study examined protein expression profiles in 65 individuals diagnosed with PCC, compared to 9 healthy controls, revealing distinct proteomic signatures that correlate with the severity of clinical symptoms. A significant outcome of this research is the development of a proteomic severity scale that aligns closely with clinical assessments, providing a new method for categorizing the severity of PCC. This scale is particularly valuable for enhancing patient management strategies and guiding therapeutic interventions. By analyzing both the plasma and pellet blood fractions, the study highlights the importance of considering all blood components in PCC research, which could lead to novel insights into the disease mechanisms. The findings indicate substantial immunological and metabolic disruptions that extend beyond the acute phase of COVID-19, suggesting that PCC may involve more complex systemic changes than previously understood. The identification of key biomarkers and pathways differentiating mild from severe PCC underscores the potential of proteomic profiling to reveal the underlying pathophysiology of long COVID and to pinpoint potential therapeutic targets, advancing the overall understanding of the condition's long-term impacts.
HostingRepository	PRIDE
AnnounceDate	2026-02-16
AnnouncementXML	Submission_2026-02-16_04:50:56.384.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Susana Bravo
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-25 08:42:01	ID requested
⏵ 1	2026-02-16 04:50:56	announced

10.1016/J.JIPH.2024.102571;

submitter keyword: SWATH-MS Technology, Disease Severity, blood fractions, Proteomics, Biomarkers,Post-COVID Condition

Susana Bravo
contact affiliation	Instituto de Investigaciones Sanitarias de Santiago de Compostela
contact email	sbbravo@gmail.com
lab head
Susana Bravo
contact affiliation	FIDIS
contact email	sbbravo@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD051740

PRIDE project URI

• PRIDE
  1. PXD051740
     1. Label: PRIDE project
     2. Name: Proteomic analysis of Post-COVID Condition: Insights from supernatant and pellet blood fractions