PXD051726

PXD051726 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Targeting Neuraminidase 4 Attenuates Kidney Fibrosis in Mice
Description	Despite significant progress in therapy, there remains a lack of substantial evidence regarding the molecular factors that lead to renal fibrosis. Neuraminidase 4 (NEU4) is an enzyme that removes sialic acids from glycoconjugates, while the function of NEU4 in chronic progressive fibrosis has not been clearly explored. Here, we find that NEU4 expression is markedly upregulated in mouse fibrotic kidneys induced by folic acid or unilateral ureter obstruction, and this elevation was observed in patients with renal fibrosis. NEU4 knockdown specifically in the kidney attenuates the epithelial-to-mesenchymal transition and the production of pro-fibrotic cytokines in male mice. Conversely, NEU4 overexpression exacerbates the progression of renal fibrosis. Mechanistically, NEU4254-388aa interacts with Yes-associated protein YAP at WW2 domain (231-263aa), promotes its translocation to the nucleus, activates its target genes, and consequently contributes to renal fibrosis. 3,5,6,7,8,3ʹ,4ʹ-Heptamethoxyflavone, a natural compound, is identified as a novel inhibitor of NEU4 and effectively protects mice from renal fibrosis in a NEU4-dependent manner. Collectively, our findings suggest that NEU4 may represent a promising therapeutic target for kidney fibrosis.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_15:01:52.906.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ping-Ting Xiao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-24 18:38:47	ID requested
⏵ 1	2025-05-06 15:01:53	announced

Publication List

10.1002/advs.202406936;
Xiao PT, Hao JH, Kuang YJ, Dai CX, Rong XL, Jiang LL, Xie ZS, Zhang L, Chen QQ, Liu EH, Targeting Neuraminidase 4 Attenuates Kidney Fibrosis in Mice. Adv Sci (Weinh), 11(39):e2406936(2024) [pubmed]

10.1002/advs.202406936;

Xiao PT, Hao JH, Kuang YJ, Dai CX, Rong XL, Jiang LL, Xie ZS, Zhang L, Chen QQ, Liu EH, Targeting Neuraminidase 4 Attenuates Kidney Fibrosis in Mice. Adv Sci (Weinh), 11(39):e2406936(2024) [pubmed]

Keyword List

submitter keyword: 4ʹ-Heptamethoxyflavone,NEU4, 3,5,6,3ʹ, YAP,7,8, renal fibrosis

submitter keyword: 4ʹ-Heptamethoxyflavone,NEU4, 3,5,6,3ʹ, YAP,7,8, renal fibrosis

Contact List

Ping-Ting Xiao
contact affiliation	Nanjing University of Chinese Medicine and China Pharmaceutical University
contact email	xptpingting@163.com
lab head
Ping-Ting Xiao
contact affiliation	China Pharmaceutical University
contact email	xptpingting@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD051726
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD051726

PRIDE project URI

Repository Record List

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