PXD051694

PXD051694 is an original dataset announced via ProteomeXchange.

Title	Loss of Parkinson’s Disease Protein 7 upregulates cytoskeletal protein Palladin and is associated with pregnancy loss
Description	Decidualization is a morphological and biochemical reprograming process in preparation for pregnancy. An impaired decidual response can lead to complications like recurrent pregnancy loss (RPL). Parkinson’s disease protein 7 (PARK7), which encodes the protein DJ-1, is renowned for its pivotal role in Parkinson's disease. It manifests a spectrum of physiological functions that hold potential implications for decidualization-related processes. In this study, we elucidate whether DJ-1 can regulate endometrial function. Our findings demonstrate that DJ-1 is expressed in the endometrium of both humans and mice, with increased levels during the time-dependent decidual transformation of human endometrial stromal cells (EnSC) coinciding with the window of implantation. Analysis of human and mice showed that loss of DJ-1 is associated with RPL. Furthermore, knockdown of DJ-1 in decidualized EnSC lead to a reduced in cell proliferation, increase of reactive oxygen species and upregulation of Palladin expression, as quantified through LC/MS. These alterations subsequently contributed to heightened polymerization, augmented cell migration, and increased cellular stiffness. Importantly, these effects were reversed upon DJ-1 overexpression. These findings collectively propose DJ-1 as a crucial regulator of cytoskeleton dynamics and decidual homeostasis, essential for early pregnancy and preventing the onset of RPL.
HostingRepository	PRIDE
AnnounceDate	2026-01-27
AnnouncementXML	Submission_2026-01-27_00:56:05.718.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ana Velic
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-24 01:56:38	ID requested
⏵ 1	2026-01-27 00:56:06	announced

Dataset with its publication pending

submitter keyword: DJ-1

Palladin

Decidualization

Recurrent pregnancy loss

Endometrium

Cytoskeleton

Madhuri Salker
contact affiliation	Forschungsinstitut für Frauengesundheit Universitäts- Frauenklinik Universitätsklinikum Tübingen Germany
contact email	Madhuri.Salker@med.uni-tuebingen.de
lab head
Ana Velic
contact affiliation	University of Tuebingen
contact email	a.velic@uni-tuebingen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD051694

PRIDE project URI

• PRIDE
  1. PXD051694
     1. Label: PRIDE project
     2. Name: Loss of Parkinson’s Disease Protein 7 upregulates cytoskeletal protein Palladin and is associated with pregnancy loss