PXD051630

PXD051630 is an original dataset announced via ProteomeXchange.

Title	Adipose Kiss1 controls aerobic exercise-related adaptive responses in adipose tissue energy homeostasis
Description	Adipose Energy Homeostasis is the important guarantee to maintain the body's energy balance. Recently, it is reported that, in the adipose cell, Kisspeptins play important role in cell proliferation, differentiation, lipid metabolism and some adipocytokine secretion, so Kisspeptins maybe the novel targets of adipose energy homeostasis regulation. Adipose tissue is the core organs that regulates adipose energy homeostasis. Our early studies observed that there is organizational difference that exercise regulated adipose energy homeostasis, and the response of the Kisspeptins to exercise is closely related to the energy state of the body, so we speculated that Kisspeptins play some important role in the exercise regulated adipose energy homeostasis. Based on the cell experiments to clarify the role of Kisspeptins in regulating adipose energy homeostasis, the role of Kisspeptins in the regulation of adipose energy homeostasis were determined in the adipose tissue of conditioned Kiss1 gene knockout mice of CRISPR/Cas9, then we use the single cell transcriptome sequencing, untargeted proteome and targeted metabolome techniques to further explore and elucidate the possible pathways and mechanisms of Kisspeptins mediated adipose energy homeostasis regulated by exercise.
HostingRepository	iProX
AnnounceDate	2024-04-22
AnnouncementXML	Submission_2024-06-20_00:14:04.758.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chunyu Liang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-21 23:49:37	ID requested
⏵ 1	2024-06-20 00:14:05	announced

Liang C, Li X, Song G, Schmidt SF, Sun L, Chen J, Pan X, Zhao H, Yan Y, Adipose Kiss1 controls aerobic exercise-related adaptive responses in adipose tissue energy homeostasis. FASEB J, 38(13):e23743(2024) [pubmed]

submitter keyword: Kiss1, Kisspeptin, Adipose tissue, Energy metabolism, Exercise, Aerobic oxidation

Yi Yan
contact affiliation	Beijing Sport University
contact email	yanyi@bsu.edu.cn
lab head
Chunyu Liang
contact affiliation	Beijing Sport University
contact email	liangxiaochun@bsu.edu.cn
dataset submitter

iProX dataset URI