PXD051588

PXD051588 is an original dataset announced via ProteomeXchange.

Title	STRUCTURE OF APOLIPOPROTEIN B100 BOUND TO LOW-DENSITY LIPOPROTEIN RECEPTOR (SDA ASPN XL DATA)
Description	Apolipoprotein B100 (apoB100) is the main structural protein on Low-density Lipoproteins (LDL) and is the principal ligand for the LDL receptor (LDLR). Because the tertiary structure of apoB100 on LDL has not been determined, the detailed molecular interaction between apoB100 and LDLR is unknown. Here we present the structures of LDL bound to the LDLR and an apoB100 nanobody complex at 4.18Å resolution and a second LDL-LDLR interface at 4.83Å resolution.
HostingRepository	PRIDE
AnnounceDate	2024-12-06
AnnouncementXML	Submission_2024-12-06_09:34:12.343.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD051588
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Anthony Ciancone
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-19 13:07:42	ID requested
⏵ 1	2024-12-06 09:34:12	announced

10.6019/PXD051588;

10.1038/S41586-024-08223-0;

submitter keyword: apolipoprotein B100, cardiovascular disease, cryo-EM, crosslinking mass spectrometry, lipoprotein metabolism,low-density lipoprotein

Francis J O'Reilly
contact affiliation	Stadtman Investigator for the Department of Sturctural Biology at the National Cancer Institute
contact email	oreillyfj@nih.gov
lab head
Anthony Ciancone
contact affiliation	NCI Post-Doctoral Researcher
contact email	cianconeam@nih.gov
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/12/PXD051588

PRIDE project URI

• PRIDE
  1. PXD051588
     1. Label: PRIDE project
     2. Name: STRUCTURE OF APOLIPOPROTEIN B100 BOUND TO LOW-DENSITY LIPOPROTEIN RECEPTOR (SDA ASPN XL DATA)