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PXD051586

PXD051586 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCytokine Priming Enhances the Antifibrotic Effects of Mesenchymal Stromal Cells Conditioned Medium Via Fibrogenic Myofibroblasts Elimination and Extracellular Matrix Degradation.
DescriptionFibrosis is a pathological scarring process characterized by persistent myofibroblasts activation with excessive accumulation of extracellular matrix (ECM). Fibrotic disorders represent an increasing burden of disease-associated morbidity and mortality worldwide for which there are limited therapeutic options. Reversing fibrosis requires the elimination of myofibroblasts, remodeling of the ECM, and regeneration of functional tissue. Multipotent mesenchymal stromal cells (MSC) have antifibrotic properties mediated by secreted factors present in their conditioned medium (MSC-CM). However, there are no standardized in vitro assays to predict the antifibrotic effects of human MSC, and, as a consequence, we lack evidence on the effect of cytokine priming on MSC’s antifibrotic effects. We hypothesize that the MSC-CM promotes fibrosis resolution in vitro and that this effect is enhanced following MSC cytokine priming.
HostingRepositoryPRIDE
AnnounceDate2025-05-06
AnnouncementXMLSubmission_2025-05-06_14:35:17.318.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMarianela Brizio
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetic acid derivatized residue; deamidated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-04-19 12:19:44ID requested
12025-05-06 14:35:18announced
Publication List
10.1186/s13287-024-03916-9;
Brizio M, Mancini M, Lora M, Joy S, Zhu S, Brilland B, Reinhardt DP, Farge D, Langlais D, Colmegna I, Cytokine priming enhances the antifibrotic effects of human adipose derived mesenchymal stromal cells conditioned medium. Stem Cell Res Ther, 15(1):329(2024) [pubmed]
Keyword List
submitter keyword: MSC, myofibroblasts,multipotent mesenchymal stromal cells, fibrosis, conditioned medium, extracellular matrix
Contact List
Marianela Brizio
contact affiliationDivision of Experimental Medicine, McGill University, Montreal, QC, Canada.
contact emailmarianela.brizio@mail.mcgill.ca
lab head
Marianela Brizio
contact affiliationMcGill University
contact emailmarianela.brizio@mail.mcgill.ca
dataset submitter
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Dataset FTP location
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