PXD051579

PXD051579 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Blood-brain barrier dysfunction in brain metastasis formation in HER2-positive breast cancer
Description	we investigated the role of bioactive molecules secreted by HER2+ BC cells in BBB dysfunction during the formation of the pre-metastatic niche before the onset of BrM. We demonstrate that systemic signaling derived from brain metastatic HER2+ primary tumors instigates BBB dysfunction
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_14:44:35.726.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ana Sofia Ribeiro
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-19 07:20:13	ID requested
⏵ 1	2025-05-06 14:44:36	announced

Publication List

Santos L, Tomatis F, Ferreira HRS, Almeida SFF, Ciputra E, Sereno J, Almeida R, Teixeira P, Ribeiro AS, Moreira JN, Silva AP, Ferreira L, Abrunhosa AJ, Gomes CM, ENPP1 induces blood-brain barrier dysfunction and promotes brain metastasis formation in human epidermal growth factor receptor 2-positive breast cancer. Neuro Oncol, 27(1):167-183(2025) [pubmed]
10.1093/neuonc/noae169;

Santos L, Tomatis F, Ferreira HRS, Almeida SFF, Ciputra E, Sereno J, Almeida R, Teixeira P, Ribeiro AS, Moreira JN, Silva AP, Ferreira L, Abrunhosa AJ, Gomes CM, ENPP1 induces blood-brain barrier dysfunction and promotes brain metastasis formation in human epidermal growth factor receptor 2-positive breast cancer. Neuro Oncol, 27(1):167-183(2025) [pubmed]

10.1093/neuonc/noae169;

Keyword List

submitter keyword: HER2+ breast cancer, BBB dysfunction, brain metastasis, secretome

submitter keyword: HER2+ breast cancer, BBB dysfunction, brain metastasis, secretome

Contact List

Célia Gomes
contact affiliation	Principal Investigator Universidade de Coimbra • Faculdade de Medicina \| University of Coimbra • Faculty of Medicine Instituto de Investigação Clínica e Biomédica de Coimbra (iCBR) \| Coimbra Institute for Clinical and Biomedical Research (iCBR)
contact email	cgomes@fmed.uc.pt
lab head
Ana Sofia Ribeiro
contact affiliation	i3S - Instituto de investigação e inovação em Saúde
contact email	aribeiro@ipatimup.pt
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD051579
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD051579

PRIDE project URI

Repository Record List

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