PXD051572

PXD051572 is an original dataset announced via ProteomeXchange.

Title	Nucleoporin complex NPP-14/24 shape perinuclear germ granule architecture and coordinate piRNA silencing
Description	Germ granules are RNA-rich biomolecular condensates regulating posttranscriptional gene expression. In C. elegans, germ granules are associated with the NPC. Mechanism by which germ granules associate with the nucleus and relevant functions remain unknown. We uncovered the function of the NPP-14/24 complex in spatially organizing perinuclear germ granules and fine-tuning the piRNA-based transcriptome surveillance and the inheritance of gene silencing.
HostingRepository	PRIDE
AnnounceDate	2025-04-14
AnnouncementXML	Submission_2025-04-13_21:03:15.738.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Donglei Zhang
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	biotinylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-18 21:49:13	ID requested
⏵ 1	2025-04-13 21:03:16	announced

Dataset with its publication pending

submitter keyword: C. elegans, nucleoporin, P granule, nuclear pore complex

Donglei Zhang
contact affiliation	Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430032, China
contact email	zhang_donglei@hust.edu.cn
lab head
Donglei Zhang
contact affiliation	Huazhong University of Science and Technology
contact email	zhang_donglei@hust.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD051572

PRIDE project URI

• PRIDE
  1. PXD051572
     1. Label: PRIDE project
     2. Name: Nucleoporin complex NPP-14/24 shape perinuclear germ granule architecture and coordinate piRNA silencing