PXD051519

PXD051519 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	nuclear insulin receptor-associated proteins in lung cancer cells
Description	We have demonstrated that the communication between macrophages and lung cancer cells via macrophage-derived insulin-like growth factor 2 (IGF2) drives lung cancer progression. As a mechanism of action, we found that insulin receptor (IR) was rapidly activated and translocated to the cytosol and nucleus in response to IGF2 stimulation, and nuclearly translocated IR was associated with chromatin. Therefore, we carried out LC-MS/MS analysis to identify the nuclear proteins associated with IR.
HostingRepository	PRIDE
AnnounceDate	2024-06-14
AnnouncementXML	Submission_2024-06-14_02:54:50.633.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hye-Young Min
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	6530A Q-TOF LC/MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-16 23:40:21	ID requested
⏵ 1	2024-06-14 02:54:51	announced

Publication List

10.1038/S41467-024-49199-9;

10.1038/S41467-024-49199-9;

Keyword List

submitter keyword: insulin receptor, nuclear protein,human, lung cancer

submitter keyword: insulin receptor, nuclear protein,human, lung cancer

Contact List

Ho-Young Lee
contact affiliation	College of Pharmacy, Seoul National University
contact email	hylee135@snu.ac.kr
lab head
Hye-Young Min
contact affiliation	Seoul National University
contact email	snoopy77@snu.ac.kr
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD051519
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD051519

PRIDE project URI

Repository Record List

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