PXD051519 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | nuclear insulin receptor-associated proteins in lung cancer cells |
Description | We have demonstrated that the communication between macrophages and lung cancer cells via macrophage-derived insulin-like growth factor 2 (IGF2) drives lung cancer progression. As a mechanism of action, we found that insulin receptor (IR) was rapidly activated and translocated to the cytosol and nucleus in response to IGF2 stimulation, and nuclearly translocated IR was associated with chromatin. Therefore, we carried out LC-MS/MS analysis to identify the nuclear proteins associated with IR. |
HostingRepository | PRIDE |
AnnounceDate | 2024-06-14 |
AnnouncementXML | Submission_2024-06-14_02:54:50.633.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Hye-Young Min |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | 6530A Q-TOF LC/MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-04-16 23:40:21 | ID requested | |
⏵ 1 | 2024-06-14 02:54:51 | announced | |
Publication List
Keyword List
submitter keyword: insulin receptor, nuclear protein,human, lung cancer |
Contact List
Ho-Young Lee |
contact affiliation | College of Pharmacy, Seoul National University |
contact email | hylee135@snu.ac.kr |
lab head | |
Hye-Young Min |
contact affiliation | Seoul National University |
contact email | snoopy77@snu.ac.kr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD051519 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD051519
- Label: PRIDE project
- Name: nuclear insulin receptor-associated proteins in lung cancer cells