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PXD051519

PXD051519 is an original dataset announced via ProteomeXchange.

Dataset Summary
Titlenuclear insulin receptor-associated proteins in lung cancer cells
DescriptionWe have demonstrated that the communication between macrophages and lung cancer cells via macrophage-derived insulin-like growth factor 2 (IGF2) drives lung cancer progression. As a mechanism of action, we found that insulin receptor (IR) was rapidly activated and translocated to the cytosol and nucleus in response to IGF2 stimulation, and nuclearly translocated IR was associated with chromatin. Therefore, we carried out LC-MS/MS analysis to identify the nuclear proteins associated with IR.
HostingRepositoryPRIDE
AnnounceDate2024-06-14
AnnouncementXMLSubmission_2024-06-14_02:54:50.633.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHye-Young Min
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
Instrument6530A Q-TOF LC/MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-04-16 23:40:21ID requested
12024-06-14 02:54:51announced
Publication List
10.1038/S41467-024-49199-9;
Keyword List
submitter keyword: insulin receptor, nuclear protein,human, lung cancer
Contact List
Ho-Young Lee
contact affiliationCollege of Pharmacy, Seoul National University
contact emailhylee135@snu.ac.kr
lab head
Hye-Young Min
contact affiliationSeoul National University
contact emailsnoopy77@snu.ac.kr
dataset submitter
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Dataset FTP location
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Repository Record List
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