PXD051504

PXD051504 is an original dataset announced via ProteomeXchange.

Title	LC-MS/MS of thoracic aorta and perivascular adipose tissue following short-term dietary methionine restriction
Description	We are exploring pathways influenced by short-term dietary methionine restriction (MR) in thoracic aorta and associated perivascular adipose tissue (PVAT) from obese C57BL/6J male mice around 26 weeks of age. Mice were fed 60% high fat diet (HFD) until they were obese, experimental mice were given 60% HFD with 0.12% methionine for 3, 5, and 10 days while the control group maintained a 60% HFD with 0.86% methionine. All mice were euthanized on the same day, then thoracic aorta was harvested, the PVAT was removed, and both sample types were prepared and analyzed separately. Three mice per group were assessed with LC-MS/MS. MR diet induced lean phenotype in PVAT, which was observed histologically, and we hypothesized that changes in lipid metabolism and mitochondrial bioenergetics mediated this response.
HostingRepository	PRIDE
AnnounceDate	2025-04-07
AnnouncementXML	Submission_2025-04-07_10:08:29.594.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Carlos Gartner
SpeciesList	scientific name: Arachis hypogaea (Peanut); NCBI TaxID: 3818;
ModificationList	biotinylated residue
Instrument	LTQ FT

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-16 14:11:48	ID requested
⏵ 1	2025-04-07 10:08:30	announced

Dataset with its publication pending

ProteomeXchange project tag: Antibodies (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: jhdfjer drtfherht dyjr tr

Marissa McGilvrey
contact affiliation	MaineHealth Institute for Research
contact email	mimcgilvrey@gmail.com
lab head
Carlos Gartner
contact affiliation	MaineHealth Institute for Research
contact email	gusti.gartner@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD051504

PRIDE project URI

• PRIDE
  1. PXD051504
     1. Label: PRIDE project
     2. Name: LC-MS/MS of thoracic aorta and perivascular adipose tissue following short-term dietary methionine restriction