⮝ Full datasets listing
PXD051469
PXD051469 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Suppression of astrocyte BMP signaling improves fragile X syndrome molecular signatures and functional deficits |
| Description | Fragile X syndrome (FXS) is a monogenic (gene = Fmr1) neurodevelopmental disorder with complex and variable manifestations spanning molecular, neuroanatomical, and behavioral changes. Prior work shows astrocytes and their secreted proteins may contribute to the pathophysiology of FXS, and that the bone morphogenetic protein (BMP) pathway may underlie some of these changes. A conditional knock out (KO) of Smad4 in astrocytes suppresses BMP signaling and lessens the severity of Fmr1 KO audiogenic seizures. Using in vivo transcriptomic and proteomic profiling of astrocytes in the mouse cortex, we find hypermetabolic gene expression programs and downregulated secretory machinery and secreted proteins in Fmr1 KO astrocytes that are moderated by Smad4 cKO. Critically, astrocyte Smad4 conditional KO restores deficits in Fmr1 KO auditory cortex inhibitory synaptic density. Thus, astrocytes can contribute to Fmr1 KO molecular and functional phenotypes, and targeting astrocytes can mitigate FXS symptoms. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-03-03 |
| AnnouncementXML | Submission_2026-03-03_18:25:56.638.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Jolene Diedrich |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-04-15 21:58:27 | ID requested | |
| ⏵ 1 | 2026-03-03 18:25:57 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Fragile X syndrome (FXS), astrocyte, bone morphogenetic protein (BMP) signaling, proteomics, secreted proteins, transcriptomics |
Contact List
| Nicola J. Allen | |
|---|---|
| contact affiliation | Salk Institute for Biological Studies |
| contact email | nallen@salk.edu |
| lab head | |
| Jolene Diedrich | |
| contact affiliation | SALK |
| contact email | jdiedrich@salk.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v07/MSV000094549/ |
