PXD051430

PXD051430 is an original dataset announced via ProteomeXchange.

Title	Differential expression of proteins in hematopoietic stem/progenitor cells lacking the Cullin-5 protein
Description	Cullin proteins are scaffolds that coordinate assembly of cullin-RING E3 ubiquitin (Ub) ligases (CRL), complexes that control post-translational ubiquitin modification and degradation of cellular proteins. Cullin-5 (Cul5) coordinates assembly of CRL complexes containing the RING E3 ligase Rbx1/2, the adapter proteins Elongins B and C, and a Suppressor of Cytokine Signalling (SOCS) box-containing substrate recognition protein. To explore potential roles for Cul5, we generated mice lacking Cul5 in the in hematopoietic system. Analyses included biological and molecular studies including proteomic analysis of differential expression of proteins in primary purified hematopoietic stem/progenitor (LSK) cells lacking Cul5.
HostingRepository	PRIDE
AnnounceDate	2025-01-26
AnnouncementXML	Submission_2025-01-26_13:26:05.972.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Dagley
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-14 19:41:31	ID requested
⏵ 1	2025-01-26 13:26:06	announced

10.1182/BLOOD.2024025406;

submitter keyword: Cullin-5,hematopietic stem and progenitor cells

LSK cells

Prof. Warren Alexander
contact affiliation	Professor Warren S Alexander The Walter and Eliza Hall Institute of Medical Research Theme Leader, Cancer Research and Treatments Laboratory Head, Blood Cells and Blood Cancer Division WEHI Professor of Medical Biology Honorary Professor, Department of Medical Biology, University of Melbourne
contact email	alexandw@wehi.edu.au
lab head
Laura Dagley
contact affiliation	WEHI
contact email	dagley.l@wehi.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD051430

PRIDE project URI

• PRIDE
  1. PXD051430
     1. Label: PRIDE project
     2. Name: Differential expression of proteins in hematopoietic stem/progenitor cells lacking the Cullin-5 protein