PXD051425

PXD051425 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	β-catenin disruption decreases macrophage exosomal α-SNAP and impedes Treg differentiation in acute liver injury
Description	Hepatic macrophages and regulatory T cells (Tregs) play an important role in the maintenance of liver immune homeostasis, but the mechanism by which hepatic macrophages regulate Tregs in acute liver injury remains largely unknown.We found that the hepatic Treg proportion and β-catenin expression in hepatic macrophages were associated with APAP and D-GalN/LPS-induced acute liver injury. Interestingly, β-catenin was significantly upregulated only in infiltrating macrophages, but not in resident Kupffer cells. Myeloid-specific β-catenin knockout mice showed an increased inflammatory cell infiltration and hepatocyte apoptosis. Moreover, myeloid β-catenin deficiency decreased the hepatic Treg proportion in the injured liver. Mechanistically, in vitro co-culture experiments revealed that macrophage β-catenin modulated its exosome composition, and influenced Tregs differentiation. Using mass spectrometry-based proteomics, we identified that macrophage β-catenin disruption decreased the level of exosomal α-SNAP, which in turn prevents Treg differentiation.
HostingRepository	PRIDE
AnnounceDate	2025-05-13
AnnouncementXML	Submission_2025-05-13_05:35:12.384.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	ruobin zong
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Exactive Plus

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-14 03:02:23	ID requested
⏵ 1	2025-05-13 05:35:13	announced

Publication List

10.1172/jci.insight.182515;
Zong R, Liu Y, Zhang M, Liu B, Zhang W, Hu H, Li C, -SNAP and impedes Treg differentiation in acute liver injury. JCI Insight, 10(1):(2024) [pubmed]

10.1172/jci.insight.182515;

Zong R, Liu Y, Zhang M, Liu B, Zhang W, Hu H, Li C, -SNAP and impedes Treg differentiation in acute liver injury. JCI Insight, 10(1):(2024) [pubmed]

Keyword List

submitter keyword: MOUSE,EXOSOME,BMDM

submitter keyword: MOUSE,EXOSOME,BMDM

Contact List

Ruobin Zong
contact affiliation	Department of Physiology, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China.
contact email	ruobinzong@163.com
lab head
ruobin zong
contact affiliation	tel:(86)13225079360
contact email	ruobinzong@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD051425
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD051425

PRIDE project URI

Repository Record List

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