PXD051415

PXD051415 is an original dataset announced via ProteomeXchange.

Title	SILAC experiment quantifying the proteomics of WT and HBO1-KO HeLa
Description	Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. We report that HBO1 functions as a lysine lactyltransferase to regulate transcription. Quantitative proteomic analysis further revealsed 95 endogenous Kla sites targeted by HBO1, with the majority located on histones.
HostingRepository	PRIDE
AnnounceDate	2024-04-13
AnnouncementXML	Submission_2024-04-12_18:53:09.285.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	siyu wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	6x(13)C labeled residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-12 18:34:29	ID requested
⏵ 1	2024-04-12 18:53:09	announced

Dataset with its publication pending

ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Epigenetic Chromatin (B/D-HPP), Human Proteome Project

submitter keyword: HeLa, LC-MSMS, HBO1, Kla

Kai Zhang
contact affiliation	Tianjin Medical University
contact email	kzhang@tmu.edu.cn
lab head
siyu wang
contact affiliation	TianJin Medical University
contact email	13753216903@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD051415

PRIDE project URI

• PRIDE
  1. PXD051415
     1. Label: PRIDE project
     2. Name: SILAC experiment quantifying the proteomics of WT and HBO1-KO HeLa