PXD051409

PXD051409 is an original dataset announced via ProteomeXchange.

Title	Murine Liver tissue on high fat diet
Description	Younger age and obesity increase the incidence and rates of metastasis of triple-negative breast cancer (TNBC), an aggressive subtype of breast cancer. The tissue microenvironment, specifically the extracellular matrix (ECM), is known to promote tumor invasion and metastasis. We sought to characterize the effect of both age and obesity on the ECM of liver tissue. We used a diet-induced obesity (DIO) model where 10-week-old female mice were fed a high-fat diet (HFD) for 12 weeks or a control chow diet (CD) where time points were every 4 weeks to monitor age and obesity. We isolated liver tissue to characterize the ECM at each time point. Utilizing proteomics, we found that the early stages of obesity were sufficient to induce distinct differences in the ECM composition of the livers. ECM proteins previously implicated in TNBC invasion, Collagen V and Collagen IV, were enriched with weight gain. Together these data implicate ECM changes in the primary tumor microenvironment as mechanisms by which age and obesity contribute to breast cancer progression.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:43:53.366.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sydney Conner
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-12 10:59:37	ID requested
1	2024-06-06 11:46:01	announced
⏵ 2	2024-10-22 06:43:53	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: obesity, liver,Murine, High-fat diet

Madeleine Oudin
contact affiliation	Tufts University
contact email	madeleine.oudin@tufts.edu
lab head
Sydney Conner
contact affiliation	Tufts University
contact email	sydney.conner@tufts.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD051409
     1. Label: PRIDE project
     2. Name: Murine Liver tissue on high fat diet