⮝ Full datasets listing
PXD051367
PXD051367 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comparative analysis of plasma protein dynamics in female patients with ST-elevation myocardial infarction and Takotsubo syndrome |
| Description | BACKGROUND: ST-elevation myocardial infarction (STEMI) and takotsubo syndrome (TS) are two distinct cardiac conditions that both result in sudden loss of cardiac dysfunction and that are difficult to distinguish clinically. This study compared plasma protein changes in STEMI and TS in female patients in the acute phase (days 0-3 post-symptom onset) and the stabilization phase (days 7, 14, and 30) to examine the molecular differences between these conditions. METHODS: Plasma proteins from STEMI and TS patients were extracted during acute and stabilization phases, and analyzed via quantitative proteomics. Differential expression and functional significance were assessed. RESULTS: During the acute phase, STEMI patients showed higher levels of myocardial inflammation and tissue damage proteins compared to TS patients, along with reduced tissue repair and anti-inflammatory proteins. In the stabilization phase, STEMI patients exhibited ongoing inflammation and disrupted lipid metabolism. Notably, ADIPOQ was consistently downregulated in STEMI patients at both phases. Comparing the acute to the stabilization phase, STEMI patients showed increased inflammatory proteins and decreased cholesterol metabolism proteins. Conversely, TS patients showed increased proteins involved in inflammation and regulatory response to counter excessive inflammation. Consistent protein changes between the acute and stabilization phases in both conditions, such as SAA2, CRP, SAA1, LBP, FGL1, AGT, MAN1A1, APOA4, COMP, and PCOLCE, suggest shared underlying pathophysiological mechanisms. CONCLUSION: This study presents protein changes in female STEMI and TS patients and identifies ADIPOQ, SAA2, CRP, SAA1, LBP, FGL1, AGT, MAN1A1, APOA4, COMP, and PCOLCE as candidates for further exploration in both therapeutic and diagnostic contexts. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-05-28 |
| AnnouncementXML | Submission_2026-05-28_00:14:14.713.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Evelin Berger |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Oxidation; Acetyl; Carbamidomethyl |
| Instrument | timsTOF HT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-04-11 05:57:43 | ID requested | |
| ⏵ 1 | 2026-05-28 00:14:15 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: ST-elevation myocardial infarction, takotsubo syndrome, plasma proteomics, temporal changes, energy metabolism, tissue remodeling, biomarkers |
Contact List
| Carina Sihlbom Wallem | |
|---|---|
| contact affiliation | Proteomics Core Facility, Sahlgrenska Academy, University of Gothenburg, |
| contact email | carina.sihlbom@gu.se |
| lab head | |
| Evelin Berger | |
| contact affiliation | University of Gothenburg |
| contact email | evelin.berger@gu.se |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v07/MSV000094514/ |
